Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.51 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7790153 | 0.82 | CTSL (0.53) | CAPN1CAPN2CTSKSIRT5CTSS | |
| SCHEMBL9227553 | 0.80 | SYK (0.62) | SYKCTSKCTSSCTSLCTSB | |
| SCHEMBL19934131 | 0.79 | SYK (0.61) | SYKCAPN1CAPN2CTSKCTSS | |
| SCHEMBL25022113 | 0.78 | SYK (0.57) | SYKSIRT2SIRT1SIRT3 | |
| SCHEMBL2670566 | 0.78 | CAPN1 (0.68) | SYKCAPN1CAPN2CTSKCTSS | |
| SCHEMBL30967604 | 0.77 | SYK (0.58) | SYKCAPN1CAPN2CTSKCTSS | |
| SCHEMBL30460045 | 0.77 | SYK (0.72) | SYKCTSKCTSSCTSLCTSB | |
| SCHEMBL615358 | 0.77 | SYK (0.72) | SYKCTSKCTSSCTSLCTSB | |
| SCHEMBL3897638 | 0.77 | SYK (0.72) | SYKCTSKCTSSCTSLCTSB | |
| SCHEMBL615359 | 0.77 | SYK (0.72) | SYKCTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159260-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000055124-A2 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |