Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 16/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7946667 | 0.99 | HTR4 (0.43) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL8306432 | 0.86 | HTR4 (0.53) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL8364693 | 0.86 | HTR4 (0.52) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL7804895 | 0.85 | HTR4 (0.42) | HTR4 | |
| SCHEMBL7799596 | 0.85 | HTR4 (0.36) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL8303718 | 0.81 | HTR4 (0.52) | HTR4 | |
| SCHEMBL7804900 | 0.81 | BRD4 (0.33) | — | |
| Bromide SCHEMBL8369649 | 0.80 | HTR4 (0.51) | HTR4 | |
| SCHEMBL7804890 | 0.80 | HTR4 (0.46) | HTR4HTR3A | |
| Hydrochloric Acid SCHEMBL7946906 | 0.80 | DRD2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975631-B1 | 5-ARYL-3-(8-AZABICYCLO[3.2.1]OCT-3-YL)-1,3,4-OXADIAZOL-2(3H)-ONE DERIVATIVES AS 5-HT4 RECEPTOR LIGANDS | SANOFI SYNTHELABO (FR) | 2001-10-04 | — | — | EP | disclosed |