Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylacetic Acid SCHEMBL29250510 | 0.89 | LMNA (0.55) | ALOX15LMNAMAPK1CASP3SENP7 | |
| Phenylacetic Acid SCHEMBL2343498 | 0.88 | ALOX15 (0.77) | ALOX15LMNAAKR1B1FFAR1MEN1 | |
| SCHEMBL503401 | 0.86 | ALOX15 (0.65) | ALOX15LMNAMAPK1CASP3SENP7 | |
| SCHEMBL27568652 | 0.85 | LMNA (0.60) | ALOX15LMNAMAPK1CASP3SENP7 | |
| Hydrochloric Acid SCHEMBL1619090 | 0.84 | ALOX15 (0.63) | ALOX15LMNAMAPK1CASP3SENP7 | |
| SCHEMBL9832704 | 0.84 | ALOX15 (0.63) | ALOX15AKR1B1FFAR1MEN1PTPN7 | |
| SCHEMBL29238253 | 0.84 | ALOX15 (0.63) | ALOX15LMNAMAPK1CASP3SENP7 | |
| Fluoride SCHEMBL11177165 | 0.84 | ALOX15 (0.63) | ALOX15LMNAMAPK1CASP3SENP7 | |
| SCHEMBL11596764 | 0.81 | NR4A2 (0.54) | ALOX15LMNAFFAR1ALDH1A1KDM4E | |
| SCHEMBL7800637 | 0.81 | LMNA (0.56) | LMNAMAPK1CASP3SENP7SENP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161421-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | Pharmacia & Upjohn Aktiebolag (SE) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000053583-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | BIOVITRUM AB (SE) | 2000-09-14 | — | — | WO | disclosed |