SCHEMBL7800928

SCHEMBL7800928

NCc1ccccc1C(F)(F)F.O=Cc1ccc(Oc2ccccc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.48
KDM4E B2RXH2 3/20 0.48
MAOB P27338 5/20 0.46
IDO1 P14902 2/20 0.42
PARP10 Q53GL7 1/20 0.40
PARP3 Q9Y6F1 1/20 0.40
LTA4H P09960 1/20 0.40
PLA2G2A P14555 1/20 0.40
AOC3 Q16853 1/20 0.39
MAPT P10636 1/20 0.39
MAOA P21397 1/20 0.39
PPARG P37231 1/20 0.38
PPARA Q07869 1/20 0.38
LMNA P02545 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
GRIN1 Q05586 1/20 0.38
GRIN2B Q13224 1/20 0.38
POLB P06746 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
HTT P42858 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7798120 0.88 MAOB (0.44) ALDH1A1KDM4EMAOBIDO1MAOA
SCHEMBL7793081 0.83 ALDH1A1 (0.51) ALDH1A1KDM4EMAOBIDO1MAPT
SCHEMBL7971168 0.77 MAOB (0.62) ALDH1A1KDM4EMAOBIDO1MAOA
SCHEMBL7798773 0.76 IDO1 (0.41) ALDH1A1KDM4EMAOBIDO1GRIN1
SCHEMBL43013 0.75 IDO1 (0.61) ALDH1A1KDM4EMAOBIDO1GRIN1
SCHEMBL97639 0.75 ALDH1A1 (0.59) ALDH1A1KDM4EPARP10PARP3LTA4H
SCHEMBL888020 0.75 ALDH1A1 (0.59) ALDH1A1KDM4EPARP10PARP3LTA4H
SCHEMBL2314319 0.75 ALDH1A1 (0.49) ALDH1A1KDM4EPARP10PARP3LTA4H
SCHEMBL7800512 0.75 LTA4H (0.47) ALDH1A1KDM4EMAOBPARP10PARP3
2-(Aminomethyl)Phenol SCHEMBL8035732 0.75 PARP10 (0.46) ALDH1A1KDM4EMAOBPARP10PARP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1076649-A1 ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME TREGA BIOSCIENCES, INC. (US) 2001-02-21 EP disclosed
US-6127381-A A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY LION BIOSCIENCE AG (DE) 2000-10-03 US disclosed
WO-1999055679-A1 ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME TREGA BIOSCIENCES, INC. (US) 1999-11-04 WO disclosed