Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of 2-(Aminomethyl)Phenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.46 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | PNLIP | P16233 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-(Aminomethyl)Phenol SCHEMBL7801377 | 0.89 | EPOR (0.45) | AKR1B1KMT2ANPC1RAB9AMAOB | |
| 2-(Aminomethyl)Phenol SCHEMBL7798293 | 0.85 | NPC1 (0.46) | SMN1; SMN2KDM4EKMT2AALDH1A1NPC1 | |
| 2-(Aminomethyl)Phenol SCHEMBL7801569 | 0.84 | PPARA (0.42) | SMN1; SMN2KDM4EKMT2AALDH1A1LMNA | |
| 2-(Aminomethyl)Phenol SCHEMBL8041391 | 0.82 | KMO (0.47) | SMN1; SMN2KMT2AFFAR1NPC1RAB9A | |
| Lysine SCHEMBL7802101 | 0.82 | LTA4H (0.42) | PARP10PARP3KMT2ALTA4H | |
| Lysine SCHEMBL7802098 | 0.82 | LTA4H (0.42) | PARP10PARP3KMT2ALTA4H | |
| Cyclohexylamine SCHEMBL7800175 | 0.75 | PARP10 (0.44) | PARP10PARP3KMT2AFFAR1ALDH1A1 | |
| 2-(Aminomethyl)Phenol SCHEMBL8025681 | 0.75 | SLC1A5 (0.45) | SMN1; SMN2KDM4EKMT2AALDH1A1NPC1 | |
| 2-(Aminomethyl)Phenol SCHEMBL8025682 | 0.75 | SLC1A5 (0.45) | SMN1; SMN2KDM4EKMT2AALDH1A1NPC1 | |
| SCHEMBL7800928 | 0.75 | ALDH1A1 (0.48) | PARP10PARP3SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |