Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 0.67 |
| ▸ | EBP | Q15125 | 4/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.67 |
| ▸ | DRD3 | P35462 | 3/20 | 0.67 |
| ▸ | HTR6 | P50406 | 3/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | PGR | P06401 | 3/20 | 0.67 |
| ▸ | EGFR | P00533 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7599819 | 0.90 | EBP (0.74) | ESR1EBPSIGMAR1KMT2AMAPT | |
| SCHEMBL7599292 | 0.90 | EBP (0.74) | ESR1EBPSIGMAR1KMT2AMAPT | |
| SCHEMBL17164687 | 0.88 | ESR1 (0.79) | ESR1EBPSIGMAR1KMT2AMAPT | |
| SCHEMBL17164682 | 0.88 | ESR1 (0.79) | ESR1EBPSIGMAR1KMT2AMAPT | |
| SCHEMBL7602293 | 0.86 | ESR1 (0.65) | ESR1EBPSIGMAR1KMT2AMAPT | |
| SCHEMBL14044785 | 0.86 | ESR1 (0.71) | ESR1EBPSIGMAR1KMT2AMAPT | |
| SCHEMBL9451189 | 0.86 | ESR1 (0.72) | ESR1EBPSIGMAR1KMT2AMAPT | |
| SCHEMBL9451187 | 0.86 | ESR1 (0.72) | ESR1EBPSIGMAR1KMT2AMAPT | |
| SCHEMBL906174 | 0.84 | HTR6 (0.77) | ESR1EBPSIGMAR1KMT2AMAPT | |
| SCHEMBL906173 | 0.84 | HTR6 (0.77) | ESR1EBPSIGMAR1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1127045-A2 | USE OF TRIPHENYLBUTENE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | AstraZeneca AB (SE) | 2001-08-29 | — | — | EP | claimed |
| WO-2000025767-A2 | USE OF TRIPHENYLBUTENE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2000-05-11 | — | — | WO | claimed |