Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 4/20 | 0.45 |
| ▸ | AGER | Q15109 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22285161 | 0.99 | ENPP2 (0.57) | ENPP2SIGMAR1PTGDR2L3MBTL1CCR5 | |
| SCHEMBL190556 | 0.99 | ENPP2 (0.57) | ENPP2SIGMAR1PTGDR2L3MBTL1CCR5 | |
| SCHEMBL6166891 | 0.94 | ENPP2 (0.48) | ENPP2SIGMAR1PTGDR2L3MBTL1CCR5 | |
| SCHEMBL28523905 | 0.88 | ENPP2 (0.51) | ENPP2SIGMAR1PTGDR2L3MBTL1CCR5 | |
| SCHEMBL6193454 | 0.88 | ENPP2 (0.52) | ENPP2SIGMAR1PTGDR2L3MBTL1CCR5 | |
| SCHEMBL27757526 | 0.86 | ENPP2 (0.52) | ENPP2SIGMAR1PTGDR2L3MBTL1CCR5 | |
| SCHEMBL29068551 | 0.86 | ENPP2 (0.52) | ENPP2SIGMAR1PTGDR2L3MBTL1CCR5 | |
| SCHEMBL1162705 | 0.85 | ENPP2 (0.42) | ENPP2SIGMAR1PTGDR2CCR5CHRM2 | |
| SCHEMBL9237582 | 0.85 | ENPP2 (0.50) | ENPP2SIGMAR1PTGDR2L3MBTL1CCR5 | |
| SCHEMBL13684267 | 0.84 | L3MBTL1 (0.63) | ENPP2SIGMAR1L3MBTL1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1078886-C | Inhibitors of beta-amyloid production | MURRILL MEDICINES CO (US) | 2002-02-06 | — | — | CN | disclosed |
| EP-0721449-B1 | INHIBITORS OF BETA-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMA INC (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0477049-B1 | Amido-3-pyrazole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI SYNTHELABO (FR) | 1999-12-01 | — | — | EP | disclosed |
| US-5977074-A | THERAPY FOR ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| US-5744493-A | POSSESS ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM AND THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1998-04-28 | — | — | US | disclosed |
| US-5744491-A | POSSESS ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM AND THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1998-04-28 | — | — | US | disclosed |
| US-5716973-A | ADMINISTERING DIFLUORO STATONE ANALOGS | MERRELL PHARMACEUTICALS INC. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5635526-A | POSSESSES ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM OR THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1997-06-03 | — | — | US | disclosed |
| US-5616592-A | USEFUL FOR DISORDERS OF CARDIOVASCULAR, GASTROINTESTINAL AND PSYCHOLOGICAL DISORDERS | SANOFI (FR) | 1997-04-01 | — | — | US | disclosed |
| US-5607958-A | NEUROTENSIN RECEPTOR BINDERS | SANOFI (FR) | 1997-03-04 | — | — | US | disclosed |
| CN-1132504-A | Inhibitors of beta-amyloid production | MURRILL MEDICINES CO (US) | 1996-10-02 | — | — | CN | disclosed |
| US-5559140-A | VIRICIDES | MERRELL PHARMACEUTICALS INC. (US) | 1996-09-24 | — | — | US | disclosed |
| EP-0565631-B1 | ANTI-VIRAL COMPOUNDS | MERRELL PHARMA INC (US) | 1996-09-18 | — | — | EP | disclosed |
| US-5420141-A | Capable of binding to neurotensin receptor | SANOFI (FR) | 1995-05-30 | — | — | US | disclosed |
| EP-0565631-A1 | ANTI-VIRAL COMPOUNDS. | MERRELL DOW PHARMA (US) | 1993-10-20 | — | — | EP | disclosed |
| WO-1992012123-A1 | ANTI-VIRAL COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-23 | — | — | WO | disclosed |
| EP-0477049-A1 | Amido-3-pyrazole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-03-25 | — | — | EP | disclosed |