Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29201740 | 0.85 | ACHE (0.62) | SIGMAR1ACHEBACE1SMN1; SMN2MAOB | |
| SCHEMBL13596996 | 0.84 | MEN1 (0.57) | SIGMAR1ACHEBACE1SMN1; SMN2MAOB | |
| SCHEMBL8825661 | 0.83 | SIGMAR1 (0.62) | SIGMAR1ACHE | |
| SCHEMBL15933891 | 0.83 | ALDH1A1 (0.53) | ACHEBACE1MAOBMEN1KMT2A | |
| SCHEMBL621695 | 0.82 | HRH3 (0.62) | SIGMAR1ACHEBACE1SMN1; SMN2MEN1 | |
| SCHEMBL1586714 | 0.81 | SIGMAR1 (0.63) | SIGMAR1ACHEBACE1SMN1; SMN2MEN1 | |
| SCHEMBL8101249 | 0.81 | SIGMAR1 (0.63) | SIGMAR1ACHEBACE1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL11534460 | 0.80 | SIGMAR1 (0.61) | SIGMAR1ACHEBACE1SMN1; SMN2MEN1 | |
| SCHEMBL8825473 | 0.80 | SLC6A3 (0.56) | — | |
| SCHEMBL8320248 | 0.80 | HRH3 (0.69) | SIGMAR1ACHEBACE1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673927-B1 | piperidines as anticholinergic agents | EISAI CO LTD (JP) | 2001-09-19 | — | — | EP | disclosed |
| EP-1116716-A1 | Piperidine and piperazine compounds for use in the treatment of Alzheimer | Eisai Co., Ltd. (JP) | 2001-07-18 | — | — | EP | disclosed |
| EP-0742207-A1 | 2-(Indan-1-one-2-yl-alkyl)-1-phenylalkyl-piperidines and processes for their preparation | Eisai Co., Ltd. (JP) | 1996-11-13 | — | — | EP | disclosed |
| EP-0673927-A1 | 4-[2-indanyl-1-one]alkylpiperidines as anticholinergic agents | Eisai Co., Ltd. (JP) | 1995-09-27 | — | — | EP | disclosed |
| EP-0579263-A1 | 1,4-Substituted piperidines as acetylchozinesterase inhibitors and their use for the treatment of Alzheimer's disease | Eisai Co., Ltd. (JP) | 1994-01-19 | — | — | EP | disclosed |
| US-5100901-A | Treatment of Alzheimer*s disease | EISAI CO., LTD. (JP) | 1992-03-31 | — | — | US | disclosed |
| US-4895841-A | Cyclic amine compounds with activity against acetylcholinesterase | EISAI CO., LTD. (JP) | 1990-01-23 | — | — | US | disclosed |
| EP-0296560-A2 | 1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease | Eisai Co., Ltd. (JP) | 1988-12-28 | — | — | EP | disclosed |