Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.62 |
| ▸ | CCR5 | P51681 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807754 | 0.94 | DRD4 (0.58) | DRD4CCR5MEN1KMT2AHTR7 | |
| SCHEMBL7802841 | 0.84 | OPRM1 (0.59) | DRD4MEN1KMT2ASIGMAR1OPRM1 | |
| SCHEMBL7811493 | 0.80 | TACR2 (0.57) | DRD4CCR5OPRM1POLB | |
| SCHEMBL7807765 | 0.80 | DRD4 (0.46) | DRD4MEN1KMT2ACACNA2D1CACNA1B | |
| SCHEMBL7815183 | 0.79 | TACR2 (0.56) | CCR5 | |
| SCHEMBL7812086 | 0.77 | GABBR2 (0.50) | DRD4MEN1KMT2APOLB | |
| SCHEMBL7802957 | 0.76 | TACR2 (0.66) | OPRM1 | |
| SCHEMBL7802820 | 0.76 | OPRL1 (0.58) | OPRM1KDM4E | |
| SCHEMBL7815271 | 0.76 | TACR2 (0.48) | — | |
| SCHEMBL7807766 | 0.73 | DRD4 (0.41) | DRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773929-B1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2001-10-31 | — | — | EP | disclosed |
| US-5654316-A | Piperidine derivatives as neurokinin antagonists | SCHERING CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |