Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7802852 | 0.94 | DRD4 (0.62) | DRD4OPRM1SIGMAR1FAAHMEN1 | |
| SCHEMBL7802820 | 0.81 | OPRL1 (0.58) | OPRM1ALDH1A1OPRL1KDM4E | |
| SCHEMBL7811904 | 0.77 | TACR2 (0.56) | CCR5ALDH1A1OPRL1KDM4E | |
| SCHEMBL7802841 | 0.77 | OPRM1 (0.59) | DRD4OPRM1SIGMAR1MEN1KMT2A | |
| SCHEMBL7812095 | 0.76 | TACR1 (0.47) | DRD4MEN1KMT2AALDH1A1 | |
| SCHEMBL7811493 | 0.74 | TACR2 (0.57) | DRD4OPRM1CCR5OPRL1 | |
| SCHEMBL7815055 | 0.73 | GABBR2 (0.53) | MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3152697 | 0.72 | DRD4 (0.71) | DRD4OPRM1SIGMAR1FAAHKMT2A | |
| Water SCHEMBL11227135 | 0.72 | DRD4 (0.54) | DRD4OPRM1SIGMAR1FAAHKMT2A | |
| Water SCHEMBL11227130 | 0.72 | DRD4 (0.54) | DRD4OPRM1SIGMAR1FAAHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773929-B1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2001-10-31 | — | — | EP | disclosed |