Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7803172 | 1.00 | CPB2 (0.40) | CPB2ALDH1A1SMN1; SMN2MAPTLMNA | |
| Lysine SCHEMBL7800671 | 0.90 | MC4R (0.40) | ALDH1A1SMN1; SMN2POLBL3MBTL1MMP2 | |
| Lysine SCHEMBL7800670 | 0.90 | MC4R (0.40) | ALDH1A1SMN1; SMN2POLBL3MBTL1MMP2 | |
| Phenylacetic Acid SCHEMBL8039166 | 0.88 | CCR5 (0.39) | ALDH1A1SMN1; SMN2POLBL3MBTL1CCR5 | |
| Phenylacetic Acid SCHEMBL7802488 | 0.88 | CCR5 (0.39) | ALDH1A1SMN1; SMN2POLBL3MBTL1CCR5 | |
| Lysine SCHEMBL8025522 | 0.88 | MMP2 (0.41) | ALDH1A1SMN1; SMN2MMP2CCR5 | |
| Lysine SCHEMBL7803083 | 0.88 | MMP2 (0.43) | ALDH1A1SMN1; SMN2MAPTL3MBTL1MMP2 | |
| Lysine SCHEMBL7803085 | 0.88 | MMP2 (0.43) | ALDH1A1SMN1; SMN2MAPTL3MBTL1MMP2 | |
| Lysine SCHEMBL7801550 | 0.87 | MMP2 (0.38) | ALDH1A1SMN1; SMN2MAPTLMNAL3MBTL1 | |
| Lysine SCHEMBL7801549 | 0.87 | MMP2 (0.38) | ALDH1A1SMN1; SMN2MAPTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |