SCHEMBL7803377

SCHEMBL7803377

NC1=NC2(CCN(C(=O)c3ccncc3)CC2)Nc2ccccc21

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 6/20 0.55
NOS1 P29475 5/20 0.55
NEK2 P51955 1/20 0.47
CYP2D6 P10635 8/20 0.47
CYP2C19 P33261 7/20 0.47
CYP3A4 P08684 6/20 0.47
TSHR P16473 4/20 0.47
CYP2C9 P11712 7/20 0.47
ALDH1A1 P00352 2/20 0.46
CYP1A2 P05177 4/20 0.45
USP2 O75604 2/20 0.45
MAPK1 P28482 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
HPGD P15428 1/20 0.45
HSD17B10 Q99714 1/20 0.45
HIF1A Q16665 2/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
NOS3 P29474 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8376638 0.99 NOS2 (0.54) NOS2NOS1NEK2CYP2D6CYP2C19
SCHEMBL7804452 0.93 NOS2 (0.57) NOS2NOS1NEK2ALDH1A1HPGD
Hydrochloric Acid SCHEMBL8378262 0.92 NOS2 (0.56) NOS2NOS1NEK2ALDH1A1HPGD
SCHEMBL7796711 0.91 NOS2 (0.58) NOS2NOS1NEK2NOS3
SCHEMBL7931778 0.90 NOS2 (0.57) NOS2NOS1NEK2ALDH1A1USP2
SCHEMBL7796668 0.90 NOS2 (0.57) NOS2NOS1NEK2CYP2D6CYP2C19
Hydrochloric Acid SCHEMBL8379932 0.90 NOS2 (0.57) NOS2NOS1NEK2NOS3
SCHEMBL7802943 0.89 NOS2 (0.61) NOS2NOS1NEK2NOS3
SCHEMBL7806816 0.89 NOS2 (0.56) NOS2NOS1NEK2CYP2C19CYP2C9
Hydrochloric Acid SCHEMBL8377866 0.89 NOS2 (0.56) NOS2NOS1NEK2CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248745-B1 MIXTURE COMPRISING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR AND A 1,2-DIHYDRO-4-AMINOQUINAZOLINE DERIVATIVE INHIBITOR OF INDUCED NITRIC OXIDE SYNTHASE (INOS); NON-STEROIDAL ANTIINFLAMMATORY AGENTS ASTRAZENECA AB (SE) 2001-06-19 US claimed
EP-1100505-A1 A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR AND A iNOS INHIBITOR AstraZeneca AB (SE) 2001-05-23 EP claimed
WO-2000000200-A1 A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR AND A iNOS INHIBITOR ASTRAZENECA AB (SE) 2000-01-06 WO claimed