SCHEMBL7804452

SCHEMBL7804452

NC1=NC2(CCN(C(=O)c3ccccc3)CC2)Nc2ccccc21

nearest known ligand 0.57

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 8/20 0.57
NOS1 P29475 6/20 0.57
NEK2 P51955 1/20 0.55
CRBN Q96SW2 2/20 0.47
NOS3 P29474 2/20 0.46
CHRM2 P08172 1/20 0.44
CHRM3 P20309 1/20 0.44
SIGMAR1 Q99720 1/20 0.43
ALDH1A1 P00352 2/20 0.43
TP53 P04637 1/20 0.43
DDB1 Q16531 1/20 0.43
HPGD P15428 1/20 0.42
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8378262 0.99 NOS2 (0.56) NOS2NOS1NEK2CRBNNOS3
SCHEMBL7796668 0.94 NOS2 (0.57) NOS2NOS1NEK2CRBNNOS3
Hydrochloric Acid SCHEMBL8377866 0.93 NOS2 (0.56) NOS2NOS1NEK2CRBNNOS3
SCHEMBL7796711 0.93 NOS2 (0.58) NOS2NOS1NEK2CRBNNOS3
SCHEMBL7803377 0.93 NOS2 (0.55) NOS2NOS1NEK2NOS3ALDH1A1
Hydrochloric Acid SCHEMBL8379791 0.92 NOS2 (0.55) NOS2NOS1NEK2NOS3ALDH1A1
SCHEMBL7931778 0.92 NOS2 (0.57) NOS2NOS1NEK2CRBNNOS3
Hydrochloric Acid SCHEMBL8376638 0.92 NOS2 (0.54) NOS2NOS1NEK2NOS3ALDH1A1
Hydrochloric Acid SCHEMBL8379932 0.92 NOS2 (0.57) NOS2NOS1NEK2CRBNNOS3
SCHEMBL7802857 0.91 NOS2 (0.53) NOS2NOS1NEK2NOS3TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248745-B1 MIXTURE COMPRISING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR AND A 1,2-DIHYDRO-4-AMINOQUINAZOLINE DERIVATIVE INHIBITOR OF INDUCED NITRIC OXIDE SYNTHASE (INOS); NON-STEROIDAL ANTIINFLAMMATORY AGENTS ASTRAZENECA AB (SE) 2001-06-19 US claimed
EP-1100505-A1 A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR AND A iNOS INHIBITOR AstraZeneca AB (SE) 2001-05-23 EP claimed
WO-2000000200-A1 A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR AND A iNOS INHIBITOR ASTRAZENECA AB (SE) 2000-01-06 WO claimed