SCHEMBL7803535

SCHEMBL7803535

CCOC(=O)CC(=O)CC(=O)c1c(C)n(Cc2ccccc2)c2ccc(C)cc12

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.58
GAA P10253 2/20 0.58
PKM P14618 2/20 0.58
LMNA P02545 2/20 0.58
KDM4E B2RXH2 1/20 0.58
ALDH1A1 P00352 3/20 0.54
KMT2A Q03164 3/20 0.49
MEN1 O00255 2/20 0.49
PLA2G2A P14555 1/20 0.48
TSHR P16473 1/20 0.48
RAD52 P43351 1/20 0.47
POLB P06746 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8292611 0.79 PLA2G2A (0.60) MAPTGAAPKMLMNAKDM4E
SCHEMBL7806959 0.76 TSHR (0.67) MAPTGAALMNAKDM4EALDH1A1
SCHEMBL803358 0.73 MAPT (1.00) MAPTGAAPKMLMNAKDM4E
SCHEMBL8978290 0.73 PLA2G2A (0.74) MAPTPKMLMNAKDM4EALDH1A1
SCHEMBL3718743 0.73 MAPT (0.69) MAPTGAAPKMLMNAKDM4E
SCHEMBL3388130 0.71 MAPT (0.76) MAPTGAAPKMLMNAKDM4E
SCHEMBL4754692 0.71 ALDH1A1 (0.65) MAPTGAAPKMLMNAKDM4E
SCHEMBL4698950 0.71 KDM4E (0.58) MAPTGAAPKMLMNAKDM4E
SCHEMBL7701611 0.71 MAPT (1.00) MAPTGAAPKMLMNAKDM4E
SCHEMBL12868171 0.71 HDAC1 (0.46) MAPTGAAPKMLMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0953875-B1 Photographic element containing yellow coupler EASTMAN KODAK CO (US) 2001-10-31 EP disclosed
EP-0953874-B1 Photographic element comprising yellow dye-forming photographic coupler EASTMAN KODAK CO (US) 2001-08-16 EP disclosed
US-6057087-A Photographic element containing yellow coupler EASTMAN KODAK COMPANY (US) 2000-05-02 US disclosed
US-6015658-A ELEMENT CONTAINING SILVER HALIDE EMULSION LAYER HAVING ASSOCIATED THEREWITH DYE FORMING COUPLER BASED ON MULTIPLY SUBSTITUTED PYRROLOYLACYLACETAMIDO COMPOUND EASTMAN KODAK COMPANY (US) 2000-01-18 US disclosed
EP-0953875-A1 Photographic element containing yellow coupler EASTMAN KODAK COMPANY (US) 1999-11-03 EP disclosed
EP-0953874-A1 Photographic element comprising yellow dye-forming photographic coupler EASTMAN KODAK COMPANY (US) 1999-11-03 EP disclosed