Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8031232 | 0.99 | MCHR1 (0.39) | MCHR1HTR1AMEN1CYP1A2CYP3A4 | |
| SCHEMBL7804107 | 0.93 | HTR1A (0.36) | HTR1AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7803871 | 0.86 | ABCB1 (0.38) | HTR1AMEN1CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL8035161 | 0.85 | ABCB1 (0.38) | HTR1AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7798306 | 0.82 | DRD2 (0.37) | HTR1AMEN1CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL8035086 | 0.82 | DRD2 (0.36) | HTR1AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7804132 | 0.81 | ACHE (0.35) | MCHR1HTR1AMEN1CYP1A2CYP3A4 | |
| SCHEMBL7804894 | 0.81 | HTR1A (0.41) | HTR1AHTR2AADRA2AADRA2CDRD4 | |
| Hydrochloric Acid SCHEMBL8031099 | 0.80 | ACHE (0.35) | MCHR1HTR1AMEN1CYP1A2CYP3A4 | |
| SCHEMBL7808760 | 0.80 | HTR1A (0.39) | HTR1AMEN1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |