Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11603196 | 0.85 | POLQ (0.48) | POLQCYP1A2CYP2C19RAB9ACYP2D6 | |
| SCHEMBL5509961 | 0.85 | RXRA (0.40) | POLQHTTKDM4EALDH1A1NR1H2 | |
| SCHEMBL12682526 | 0.83 | POLQ (0.50) | POLQCYP1A2CYP2C19RAB9ACYP2D6 | |
| SCHEMBL936487 | 0.83 | NOS3 (0.48) | POLQCYP1A2CYP2C19RAB9ACYP2D6 | |
| SCHEMBL192931 | 0.82 | POLQ (0.46) | POLQCYP1A2CYP2C19RAB9ACYP2D6 | |
| SCHEMBL805479 | 0.82 | POLQ (0.52) | POLQCYP1A2CYP2C19RAB9ACYP2D6 | |
| SCHEMBL29465609 | 0.82 | POLQ (0.46) | POLQCYP1A2CYP2C19RAB9ACYP2D6 | |
| SCHEMBL1693375 | 0.82 | POLQ (0.46) | POLQCYP1A2CYP2C19RAB9ACYP2D6 | |
| SCHEMBL30098378 | 0.82 | POLQ (0.46) | POLQCYP1A2CYP2C19RAB9ACYP2D6 | |
| SCHEMBL119225 | 0.82 | POLQ (0.46) | POLQCYP1A2CYP2C19RAB9ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253548-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2021-08-19 | — | — | US | disclosed |
| US-10899732-B2 | Substituted benzamides useful as sodium channel blockers | GENENTECH, INC. (US) | 2021-01-26 | — | — | US | disclosed |
| US-20180346441-A1 | SUBSTITUTED BENZAMIDES USEFUL AS SODIUM CHANNEL BLOCKERS | GENENTECH, INC. (US) | 2018-12-06 | — | — | US | disclosed |
| EP-2945932-B1 | COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE | ALLERGAN INC (US) | 2018-11-21 | — | — | EP | disclosed |
| CN-108495851-A | Substituted benzamide and its application method | 基因泰克公司 | 2018-09-04 | — | — | CN | disclosed |
| US-9394284-B2 | Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response | ALLERGAN, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| EP-2945932-A1 | COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE | ALLERGAN, INC. (US) | 2015-11-25 | — | — | EP | disclosed |
| CN-105008331-A | COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE | ALLERGAN INC | 2015-10-28 | — | — | CN | disclosed |
| US-20150080446-A1 | COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE | ALLERGAN, INC. | 2015-03-19 | — | — | US | disclosed |
| US-8859606-B2 | Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response | ALLERGAN, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| WO-2014113814-A1 | COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE | ALLERGAN, INC. (US) | 2014-07-24 | — | — | WO | disclosed |
| US-20130131135-A1 | COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE | ALLERGAN, INC. (US) | 2013-05-23 | — | — | US | disclosed |
| JP-2001097937-A | METHOD FOR PRODUCING 4-FLUORO-2- TRIFLUOROMETHYLBENZONITRILE | CENTRAL GLASS CO LTD | 2001-04-10 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150080446-A1 | COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE | PTGER1, PTGER4, CNR1 | POLQ 4778/4885CYP1A2 482/4885CYP2C19 842/4885 |
| US-20180346441-A1 | SUBSTITUTED BENZAMIDES USEFUL AS SODIUM CHANNEL BLOCKERS | SCN2B, SCN1B, CACNA1E | POLQ 4270/4885CYP1A2 864/4885CYP2C19 1754/4885 |
| US-20130131135-A1 | COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE | PTGER1, PTGER4, CNR1 | POLQ 4778/4885CYP1A2 482/4885CYP2C19 842/4885 |
| US-10899732-B2 | Substituted benzamides useful as sodium channel blockers | SCN2B, SCN1B, CACNA1E | POLQ 4270/4885CYP1A2 864/4885CYP2C19 1754/4885 |
| US-20210253548-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | RDX, RRM1, BRIX1 | POLQ 2523/4885CYP1A2 55/4885CYP2C19 170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.