Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811907 | 0.86 | KDM4E (0.44) | KMT2AALDH1A1MEN1POLBSLC6A9 | |
| SCHEMBL4175324 | 0.83 | KMT2A (0.49) | KMT2AALDH1A1MEN1POLBSLC6A9 | |
| SCHEMBL3295365 | 0.78 | ALDH1A1 (0.43) | KMT2AALDH1A1MEN1POLBSLC6A9 | |
| SCHEMBL20594076 | 0.76 | KMT2A (0.57) | KMT2AALDH1A1MEN1SLC6A9OPRD1 | |
| SCHEMBL85386 | 0.74 | ALDH1A1 (0.54) | KMT2AALDH1A1MEN1SLC6A9OPRD1 | |
| SCHEMBL5461890 | 0.74 | ALDH1A1 (0.51) | KMT2AALDH1A1MEN1SLC6A9OPRD1 | |
| SCHEMBL12499368 | 0.71 | ALDH1A1 (0.51) | KMT2AALDH1A1MEN1SLC6A9OPRD1 | |
| SCHEMBL3296869 | 0.71 | CACNA2D1 (0.51) | SLC6A9CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL24873255 | 0.71 | ALDH1A1 (0.48) | KMT2AALDH1A1MEN1SLC6A9OPRD1 | |
| SCHEMBL72964 | 0.71 | CYP3A4 (0.49) | KMT2AALDH1A1MEN1SLC6A9OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775132-B1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LTD (GB) | 2001-03-28 | — | — | EP | disclosed |
| US-5968923-A | ANTIINFLAMMATORY AGENTS, TREATMENT OF NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS | PFIZER INC. (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0775132-A1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | Pfizer Limited (GB) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005193-A1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |