Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | BUB1 | O43683 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7804645 | 0.86 | KMT2A (0.46) | ALDH1A1KMT2AMEN1POLBSLC6A9 | |
| SCHEMBL3295365 | 0.80 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1POLBSLC6A9 | |
| SCHEMBL4175324 | 0.80 | KMT2A (0.49) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL7817761 | 0.78 | SLC6A3 (0.40) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL72964 | 0.74 | CYP3A4 (0.49) | ALDH1A1KMT2AMEN1SLC6A9OPRD1 | |
| SCHEMBL20594076 | 0.73 | KMT2A (0.57) | KDM4EALDH1A1KMT2AMEN1SLC6A9 | |
| SCHEMBL5458127 | 0.73 | ALDH1A1 (0.46) | KDM4EALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL85386 | 0.71 | ALDH1A1 (0.54) | KDM4EALDH1A1KMT2AMEN1SLC6A9 | |
| SCHEMBL70442 | 0.71 | KDM4E (0.42) | KDM4EALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5461890 | 0.71 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1SLC6A9OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775132-B1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LTD (GB) | 2001-03-28 | — | — | EP | disclosed |
| US-5968923-A | ANTIINFLAMMATORY AGENTS, TREATMENT OF NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS | PFIZER INC. (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1996005193-A1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |