Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9810581 | 0.89 | ALDH1A1 (0.51) | MEN1KMT2ATSHRALDH1A1POLB | |
| SCHEMBL18100266 | 0.86 | FPR2 (0.51) | MEN1KMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL18100263 | 0.86 | FPR2 (0.51) | MEN1KMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL18093639 | 0.86 | FPR2 (0.51) | MEN1KMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL9810410 | 0.86 | LMNA (0.53) | MEN1KMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL7973187 | 0.86 | MEN1 (0.49) | MEN1KMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL7973185 | 0.86 | MEN1 (0.49) | MEN1KMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL9810263 | 0.85 | KMT2A (0.54) | KMT2AMAPTTSHRALDH1A1POLB | |
| SCHEMBL9810531 | 0.85 | GAA (0.51) | MEN1KMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL9810389 | 0.84 | OPRM1 (0.43) | MEN1KMT2AMAPTTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681569-B1 | SPIROCYCLOALKYL-SUBSTITUTED AZETIDINONES USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORP (US) | 2001-03-21 | — | — | EP | disclosed |
| US-5698548-A | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents | SCHERING CORPORATION (US) | 1997-12-16 | — | — | US | disclosed |
| CN-1118163-A | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents | SCHERING CORP (US) | 1996-03-06 | — | — | CN | disclosed |
| EP-0681569-A1 | SPIROCYCLOALKYL-SUBSTITUTED AZETIDINONES USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORPORATION (US) | 1995-11-15 | — | — | EP | disclosed |
| WO-1994017038-A1 | SPIROCYCLOALKYL-SUBSTITUTED AZETIDINONES USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORPORATION (US) | 1994-08-04 | — | — | WO | disclosed |