SCHEMBL7804828

SCHEMBL7804828

COc1ccc(F)cc1C(=O)c1cnccc1C(=O)O

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
KDM4C Q9H3R0 6/20 0.42
CDC25B P30305 1/20 0.41
ALDH1A1 P00352 1/20 0.41
PIN1 Q13526 3/20 0.40
GPBAR1 Q8TDU6 1/20 0.40
STIM1 Q13586 1/20 0.39
ORAI1 Q96D31 1/20 0.39
ALPL P05186 1/20 0.39
LMNA P02545 1/20 0.39
MAPK1 P28482 1/20 0.39
HTT P42858 1/20 0.39
RAB9A P51151 1/20 0.39
CDK1 P06493 1/20 0.39
CDK4 P11802 1/20 0.39
CCND1 P24385 1/20 0.39
CDK2 P24941 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7804812 0.95 DHODH (0.43) DHODHL3MBTL1KDM4CCDC25BALDH1A1
SCHEMBL7766931 0.82 CES2 (0.47) L3MBTL1KDM4CALDH1A1
SCHEMBL31006674 0.80 GPBAR1 (0.50) DHODHKDM4CGPBAR1STIM1ORAI1
SCHEMBL29622845 0.80 KEAP1 (0.53) DHODHALDH1A1PIN1LMNAMAPK1
SCHEMBL113562 0.80 KEAP1 (0.53) DHODHALDH1A1PIN1LMNAMAPK1
SCHEMBL7804796 0.78 KDM4C (0.46) KDM4CLMNAMAPK1HTTRAB9A
SCHEMBL7817958 0.78 KDM4C (0.44) DHODHKDM4C
SCHEMBL30465506 0.76 KDM4C (0.49) L3MBTL1KDM4CALDH1A1HTT
SCHEMBL668446 0.76 KDM4C (0.49) L3MBTL1KDM4CALDH1A1HTT
SCHEMBL7772555 0.76 CES2 (0.47) L3MBTL1KDM4CALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0750619-B1 HETERO-ANNULATED INDAZOLES NOVUSPHARMA SPA (IT) 2001-05-30 EP disclosed
EP-0662076-B1 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY UNIV VERMONT (US) 2001-04-11 EP disclosed
US-5604246-A HAVING POTENCY AGAINST MULTIDRUG RESISTANT TUMORS BOEHRINGER MANNHEIM ITALIA SPA (IT) 1997-02-18 US disclosed
US-5596097-A ANTITUMOR AGENTS THE UNIVERSITY OF VERMONT (US) 1997-01-21 US disclosed
EP-0750619-A1 HETERO-ANNULATED INDAZOLES BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) 1997-01-02 EP disclosed
US-5519029-A ANTITUMOR AGENTS BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) 1996-05-21 US disclosed
WO-1995024407-A1 HETERO-ANNULATED INDAZOLES BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) 1995-09-14 WO disclosed
EP-0662076-A1 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY THE UNIVERSITY OF VERMONT (US) 1995-07-12 EP disclosed
WO-1994006795-A1 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY THE UNIVERSITY OF VERMONT (US) 1994-03-31 WO disclosed