SCHEMBL668446

SCHEMBL668446

COc1ccncc1C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 5/20 0.49
ALDH1A1 P00352 5/20 0.48
KDM4E B2RXH2 3/20 0.48
TDP1 Q9NUW8 3/20 0.48
MAPT P10636 2/20 0.48
KDM6B O15054 2/20 0.48
MEN1 O00255 1/20 0.48
KDM4A O75164 1/20 0.48
THRB P10828 1/20 0.48
KMT2A Q03164 1/20 0.48
KDM4D Q6B0I6 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
CA12 O43570 2/20 0.47
CA1 P00915 2/20 0.47
CA2 P00918 2/20 0.47
CA9 Q16790 2/20 0.47
HPGD P15428 1/20 0.44
HTT P42858 1/20 0.44
GLA P06280 1/20 0.43
GAA P10253 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30465506 1.00 KDM4C (0.49) KDM4CALDH1A1KDM4ETDP1MAPT
SCHEMBL3464020 0.98 KDM4C (0.47) KDM4CALDH1A1KDM4ETDP1MAPT
Hydrochloric Acid SCHEMBL11590758 0.98 KDM4C (0.47) KDM4CALDH1A1KDM4ETDP1MAPT
SCHEMBL115719 0.85 KDM4C (0.53) KDM4CALDH1A1KDM4ETDP1MAPT
SCHEMBL30578227 0.85 KDM4C (0.53) KDM4CALDH1A1KDM4ETDP1MAPT
SCHEMBL334854 0.85 CA12 (0.47) ALDH1A1KDM4ETDP1MAPTKMT2A
SCHEMBL9646602 0.83 KDM4E (0.59) ALDH1A1KDM4EMAPTKMT2AL3MBTL1
SCHEMBL11590754 0.83 CA12 (0.46) KDM4CALDH1A1KDM4ETDP1MAPT
Hydrochloric Acid SCHEMBL459608 0.83 KDM4C (0.52) KDM4CALDH1A1KDM4ETDP1MAPT
SCHEMBL3966553 0.83 SIRT3 (0.59) ALDH1A1KDM4ETDP1CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111295382-B Bridged bicyclic compounds as farnesyl ester X receptor modulators 百时美施贵宝公司 2024-02-02 CN claimed
CN-106986789-A Hydroquinone compound and preparation method thereof and the application in antitumor or immunological regulation 中国人民解放军军事医学科学院生物医学分析中心 2017-07-28 CN claimed
EP-3856179-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-05-13 EP disclosed
EP-4727943-A1 INHIBITORS OF MET KINASE Celyn Therapeutics, Inc. (US) 2026-04-22 EP disclosed
US-12595245-B2 Inhibitors of MET kinase CELYN THERAPEUTICS, INC. (US) 2026-04-07 US disclosed
US-20260055097-A9 NRF2 PROTEIN DEGRADERS GANYMEDE ONCOLOGY INC (US) 2026-02-26 US disclosed
WO-2025235833-A1 RXFP1 RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2025-11-13 WO disclosed
US-20250145611-A1 NRF2 PROTEIN DEGRADERS GANYMEDE ONCOLOGY, INC. 2025-05-08 US disclosed
CN-118955471-B Polysubstituted piperazine compound with double chiral centers, and preparation method and application thereof 河源市深河人民医院(暨南大学附属第五医院) 2025-04-18 CN disclosed
CN-119707919-A Deuterated piperazine compound and preparation method and application thereof 山东大学 2025-03-28 CN disclosed
WO-2024259060-A1 INHIBITORS OF MET KINASE KINNATE BIOPHARMA INC. (US) 2024-12-19 WO disclosed
US-20040122014-A1 Muscarinic M2 receptor antagonists; such as 4-{N-[7-(3-1-carbamoyl-1,1-diphenylmethyl)pyrrolidin-1-yl)hept-1-yl]-N-(isopropyl)amino}-1-(4-methoxypyrid-3-ylmethyl)piperidine; reduced blurred vision, constipation and dry mouth side effects THERAVANCE BIOPHARMA R&D IP, LLC 2004-06-24 US disclosed
WO-2004041806-A2 SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL) PIPERIDINE AS MUSCARINIC RECEPTOR ANTAGONISTS THERAVANCE, INC. (US) 2004-05-21 WO disclosed
US-20040058937-A1 Heterocyclic mutilin esters and their use as antibacterials SMITHKLINE BEECHAM P.L.C. (GB) 2004-03-25 US disclosed
EP-1309565-A1 HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2003-05-14 EP disclosed
US-20020103392-A1 CORTICOID-17,21-DICARBOXYLIC ESTERS AND CORTICOSTEROID 17-CARBOXYLIC ESTER 21-CARBONIC ESTERS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-08-01 US disclosed
WO-2002012199-A1 HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM P.L.C. (GB) 2002-02-14 WO disclosed
US-5608093-A ANTIINFLAMMATORY AGENTS HOECHST AKTIENGESELLSCHAFT (DE) 1997-03-04 US disclosed
EP-0640616-A2 17-Alkylcarbonate, 21-0-carbonic/carboxylic acid esters of corticosteroids, a method for their production and pharmaceutical compositions containing them HOECHST AKTIENGESELLSCHAFT (DE) 1995-03-01 EP disclosed
EP-0306251-A2 Azolidinedione derivatives PFIZER INC. (US) 1989-03-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040122014-A1 Muscarinic M2 receptor antagonists; such as 4-{N-[7-(3-1-carbamoyl-1,1-diphenylmethyl)pyrrolidin-1-yl)hept-1-yl]-N-(isopropyl)amino}-1-(4-methoxypyrid-3-ylmethyl)piperidine; reduced blurred vision, constipation and dry mouth side effects CHRM2, CHRM1, CHRM3 KDM4C 1973/4885ALDH1A1 1429/4885KDM4E 2117/4885
US-20040058937-A1 Heterocyclic mutilin esters and their use as antibacterials MLN, MSH2, MRPL21 KDM4C 4721/4885ALDH1A1 852/4885KDM4E 4142/4885
US-12595245-B2 Inhibitors of MET kinase MET, ABL1, ERBB2 KDM4C 721/4885ALDH1A1 2585/4885KDM4E 393/4885
US-20020103392-A1 CORTICOID-17,21-DICARBOXYLIC ESTERS AND CORTICOSTEROID 17-CARBOXYLIC ESTER 21-CARBONIC ESTERS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS NR3C1, HSD3B1, HSD17B7 KDM4C 1319/4885ALDH1A1 1867/4885KDM4E 2072/4885
US-20260055097-A9 NRF2 PROTEIN DEGRADERS KEAP1, NFE2L2, NFE2 KDM4C 922/4885ALDH1A1 1094/4885KDM4E 1719/4885
US-20250145611-A1 NRF2 PROTEIN DEGRADERS KEAP1, NFE2L2, NFE2 KDM4C 794/4885ALDH1A1 1500/4885KDM4E 643/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.