Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 14/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7772555 | 0.94 | CES2 (0.47) | CES2CES1KDM4CALDH1A1L3MBTL1 | |
| SCHEMBL7804698 | 0.87 | TGFBR1 (0.47) | KDM4CALDH1A1L3MBTL1KDM4EMEN1 | |
| SCHEMBL7823403 | 0.83 | CES2 (0.52) | CES2CES1ALDH1A1KDM4EMEN1 | |
| SCHEMBL7804828 | 0.82 | DHODH (0.43) | KDM4CALDH1A1L3MBTL1 | |
| SCHEMBL7812042 | 0.81 | TGFBR1 (0.47) | KDM4CALDH1A1L3MBTL1KDM4EMEN1 | |
| SCHEMBL7843027 | 0.80 | LTA4H (0.58) | KDM4CALDH1A1L3MBTL1KDM4EMEN1 | |
| SCHEMBL27673772 | 0.78 | CES2 (0.74) | CES2CES1ALDH1A1MEN1KMT2A | |
| SCHEMBL7804812 | 0.76 | DHODH (0.43) | KDM4CALDH1A1L3MBTL1 | |
| SCHEMBL30316868 | 0.76 | KDM4C (0.53) | KDM4CALDH1A1L3MBTL1KDM4EMEN1 | |
| SCHEMBL229353 | 0.76 | KDM4C (0.53) | KDM4CALDH1A1L3MBTL1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752857-B1 | AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS (2-AMINOETHYL)AMINO]BENZO g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT | NOVUSPHARMA SPA (IT) | 2001-07-25 | — | — | EP | claimed |
| EP-0752857-A1 | AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS (2-AMINOETHYL)AMINO]BENZO g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-15 | — | — | EP | claimed |
| WO-1995026189-A1 | AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS[(2-AMINOETHYL)AMINO]BENZO[g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT | BOEHRINGER MANNHEIM ITALIA, S.P.A. (US) | 1995-10-05 | — | — | WO | claimed |
| EP-0752857-B1 | AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS (2-AMINOETHYL)AMINO]BENZO g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT | NOVUSPHARMA SPA (IT) | 2001-07-25 | — | — | EP | disclosed |
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| EP-0662076-B1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | UNIV VERMONT (US) | 2001-04-11 | — | — | EP | disclosed |
| US-6034092-A | ANTITUMOR, ANTICANCER AGENTS | NOVUSPHARMA S.P.A. (IT) | 2000-03-07 | — | — | US | disclosed |
| EP-0876369-A1 | 2- 2- (2-HYDROXYETHYL)AMINO]ETHYL]-5- 2-METHYLAMINO)ETHYL]AMINO]INDAZOLO 4,3-gh]ISOQUINOLIN-6(2H)-ONE AS ANTITUMOR AGENT | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1998-11-11 | — | — | EP | disclosed |
| EP-0639183-B1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA (IT) | 1998-07-01 | — | — | EP | disclosed |
| US-5717099-A | Method of synthesis for 6,9-bis((2-aminoethyl)amino)benzo g!isoquinoline-5,10-dione and its dimaleate salt | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1998-02-10 | — | — | US | disclosed |
| EP-0503537-B1 | 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones | UNIV VERMONT (US) | 1997-05-14 | — | — | EP | disclosed |
| US-5506232-A | 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1996-04-09 | — | — | US | disclosed |
| WO-1995026189-A1 | AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS[(2-AMINOETHYL)AMINO]BENZO[g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT | BOEHRINGER MANNHEIM ITALIA, S.P.A. (US) | 1995-10-05 | — | — | WO | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |
| EP-0662076-A1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1995-07-12 | — | — | EP | disclosed |
| WO-1994006795-A1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1994-03-31 | — | — | WO | disclosed |
| EP-0575526-A1 | 6,9 BIS(SUBSTITUTED-AMINO)BENZO g]ISOQUINOLINE-5,10-DIONES | THE UNIVERSITY OF VERMONT (US) | 1993-12-29 | — | — | EP | disclosed |
| WO-1992015300-A1 | 6,9 BIS(SUBSTITUTED-AMINO)BENZO[g]ISOQUINOLINE-5,10-DIONES | THE UNIVERSITY OF VERMONT (US) | 1992-09-17 | — | — | WO | disclosed |
| WO-1992015566-A1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-09-17 | — | — | WO | disclosed |
| EP-0503537-A1 | 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones | THE UNIVERSITY OF VERMONT (US) | 1992-09-16 | — | — | EP | disclosed |