Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3507796 | 0.87 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTKDM4EPKM | |
| SCHEMBL7804195 | 0.84 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPTNR1D1KDM4E | |
| SCHEMBL7808872 | 0.84 | NR1H2 (0.44) | KDM4EPKMUSP30GPR119FEN1 | |
| SCHEMBL7943896 | 0.82 | GPR119 (0.46) | ALDH1A1KDM4EGPR119 | |
| SCHEMBL15522269 | 0.81 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTGPR119DRD2 | |
| SCHEMBL3354696 | 0.80 | HTR7 (0.58) | ALDH1A1MAPTHTR7PKMAR | |
| SCHEMBL3354815 | 0.80 | MAPT (0.52) | ALDH1A1LMNAMAPTKDM4EGPR119 | |
| SCHEMBL7804105 | 0.80 | GPR119 (0.41) | KDM4EPKMUSP30GPR119TGFBR1 | |
| SCHEMBL7804911 | 0.79 | GPR119 (0.47) | ALDH1A1LMNAMAPTNR1D1KDM4E | |
| SCHEMBL7805941 | 0.77 | HTR7 (0.53) | ALDH1A1LMNAMAPTHTR7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| US-6046205-A | FOR TREATMENT OF VENOUS INSUFFICIENCY AND OF ASSOCIATED DISORDERS, AND ALSO IN THE TREATMENT OF MIGRAINE | ADIR ET COMPAGNIE (FR) | 2000-04-04 | — | — | US | disclosed |
| US-6020336-A | Indole and indazole compounds | LES LABORATOIRES SERVIER (FR) | 2000-02-01 | — | — | US | disclosed |