Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | AGXT | P21549 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7810789 | 0.83 | TSHR (0.48) | TSHRL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1233184 | 0.71 | TSHR (0.45) | TSHRL3MBTL1RAB9ASMN1; SMN2POLB | |
| SCHEMBL4766105 | 0.70 | ALDH1A1 (0.37) | TSHRL3MBTL1SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL27380 | 0.69 | TSHR (1.00) | TSHRIDO1POLBAGXTALDH1A1 | |
| Benzene SCHEMBL27997624 | 0.69 | TSHR (1.00) | TSHRIDO1POLBAGXTALDH1A1 | |
| SCHEMBL5311581 | 0.69 | TSHR (1.00) | TSHRIDO1POLBAGXTALDH1A1 | |
| SCHEMBL1041180 | 0.68 | TSHR (0.50) | TSHRL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31456660 | 0.68 | TSHR (0.46) | TSHRL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25248533 | 0.67 | L3MBTL1 (0.36) | TSHRL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16013582 | 0.67 | ADORA3 (0.49) | TSHRL3MBTL1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0854721-B1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6127371-A | FOR TREATMENT OR PREVENTION OF CARDIOVASCULAR AND RENAL DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| US-5985886-A | USEFUL IN THE TREATMENT OF A VARIETY OF CARDIOVASCULAR AND RENAL DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-16 | — | — | US | disclosed |
| US-5942516-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1999-08-24 | — | — | US | disclosed |
| EP-0854721-A4 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1998-12-02 | — | — | EP | disclosed |
| EP-0854721-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-07-29 | — | — | EP | disclosed |
| WO-1997004781-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-13 | — | — | WO | disclosed |