Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16993027 | 0.87 | HSD17B10 (0.44) | MTNR1AMTNR1BHSP90AB1SMN1; SMN2CYP3A4 | |
| SCHEMBL3144672 | 0.81 | SMN1; SMN2 (0.51) | MTNR1AMTNR1BSMN1; SMN2CYP3A4HDAC3 | |
| SCHEMBL23362766 | 0.79 | SMN1; SMN2 (0.52) | SMN1; SMN2CYP3A4ALDH1A1HPGDCSNK1D | |
| SCHEMBL30296102 | 0.79 | SMN1; SMN2 (0.52) | SMN1; SMN2CYP3A4ALDH1A1HPGDCSNK1D | |
| SCHEMBL31062479 | 0.79 | HSP90AB1 (0.38) | MTNR1AMTNR1BHSP90AB1PDGFRBFGFR1 | |
| SCHEMBL29420185 | 0.77 | CYP3A4 (0.62) | MTNR1AMTNR1BHSP90AB1CYP3A4HMGCR | |
| SCHEMBL2399645 | 0.77 | MTNR1A (0.49) | MTNR1AMTNR1BHSP90AB1CYP3A4HMGCR | |
| SCHEMBL7802421 | 0.76 | PDE4A (0.50) | HMGCRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10268100 | 0.75 | ALDH1A1 (0.44) | MTNR1AMTNR1BHSP90AB1PDGFRBFGFR1 | |
| SCHEMBL17522160 | 0.74 | DPP4 (0.46) | MTNR1AMTNR1BSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787127-B1 | 5-LIPOXYGENASE INHIBITORS | PFIZER (US) | 2001-01-03 | — | — | EP | disclosed |
| US-6063928-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, CARDIOTONIC AGENTS | PFIZER INC (US) | 2000-05-16 | — | — | US | disclosed |
| US-5883106-A | 5-lipoxygenase inhibitors | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0787127-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1997-08-06 | — | — | EP | disclosed |
| WO-1996011911-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1996-04-25 | — | — | WO | disclosed |