Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 4/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.30 |
| ▸ | KDM4A | O75164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154099 | 0.91 | MAPT (0.39) | PDE7ACYP19A1TDP1MAPTMEN1 | |
| SCHEMBL6351555 | 0.86 | PDE7A (0.48) | PDE7ACYP19A1TRPV1MAPTMEN1 | |
| SCHEMBL20476508 | 0.77 | CYP19A1 (0.43) | PDE7ACYP19A1TRPV1TDP1MAPT | |
| SCHEMBL3772645 | 0.73 | PDE7A (0.49) | PDE7ACYP19A1TDP1MAPTMEN1 | |
| SCHEMBL6348646 | 0.69 | PDE7A (0.55) | PDE7ATRPV1TDP1MAPTMEN1 | |
| SCHEMBL9187475 | 0.65 | ALDH1A1 (0.50) | PDE7ATRPV1MAPTMEN1KMT2A | |
| SCHEMBL15292815 | 0.64 | VCAM1 (0.45) | MAPTMEN1KMT2AHTTHPGD | |
| SCHEMBL8154102 | 0.63 | ABCB1 (0.32) | — | |
| SCHEMBL11453922 | 0.63 | MAPT (0.66) | TDP1MAPTMEN1KMT2AHTT | |
| SCHEMBL31283045 | 0.62 | ALDH1A1 (0.49) | PDE7ACYP19A1TDP1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082110-A1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | AstraZeneca AB (SE) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062506-A1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | disclosed |