Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 6/20 | 0.38 |
| ▸ | PDE7B | Q9NP56 | 3/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.38 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.36 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807741 | 0.91 | PDE7A (0.38) | MAPTMEN1KMT2AGAATDP1 | |
| SCHEMBL3772645 | 0.84 | PDE7A (0.49) | MAPTMEN1KMT2AGAATDP1 | |
| SCHEMBL6351555 | 0.75 | PDE7A (0.48) | MAPTMEN1KMT2APDE7APDE7B | |
| SCHEMBL8154102 | 0.71 | ABCB1 (0.32) | — | |
| SCHEMBL6565670 | 0.70 | HSD17B10 (0.52) | MAPTMEN1KMT2AGAATDP1 | |
| SCHEMBL2904377 | 0.70 | ALDH1A1 (0.56) | MAPTMEN1KMT2ATDP1PDE7A | |
| SCHEMBL20476508 | 0.68 | CYP19A1 (0.43) | MAPTMEN1KMT2ATDP1PDE7A | |
| SCHEMBL2419394 | 0.68 | PDE7A (0.56) | MAPTMEN1KMT2ATDP1PDE7A | |
| SCHEMBL13401628 | 0.68 | GPR35 (0.51) | MAPTMEN1KMT2AGAATDP1 | |
| SCHEMBL10786431 | 0.68 | PDE7A (0.74) | MAPTMEN1KMT2ATDP1PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1059927-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | AstraZeneca AB (SE) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999044618-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 1999-09-10 | — | — | WO | disclosed |