Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5144782 | 0.87 | SMN1; SMN2 (0.44) | KMT2AHPGDMEN1ALDH1A1MAPK1 | |
| SCHEMBL5144382 | 0.87 | RAB9A (0.35) | KMT2AHPGDALDH1A1HTTBTN3A1 | |
| SCHEMBL878441 | 0.83 | BTN3A1 (0.43) | ALDH1A1HTTBTN3A1L3MBTL1KDM4E | |
| SCHEMBL6708631 | 0.76 | LMNA (0.42) | KMT2AMEN1ALDH1A1MAPK1LMNA | |
| SCHEMBL28621325 | 0.75 | CA1 (0.56) | KMT2AHPGDMEN1CYP1A2CYP3A4 | |
| SCHEMBL858403 | 0.74 | BTN3A1 (0.40) | HPGDHTTMAPK1BTN3A1L3MBTL1 | |
| SCHEMBL878407 | 0.74 | BTN3A1 (0.42) | KMT2AHPGDMEN1ALDH1A1HTT | |
| SCHEMBL7806320 | 0.73 | RAB9A (0.34) | KMT2AHPGDMEN1ALDH1A1HTT | |
| SCHEMBL643837 | 0.71 | BTN3A1 (0.40) | HPGDHTTMAPK1BTN3A1L3MBTL1 | |
| SCHEMBL877722 | 0.71 | TDP1 (0.41) | ALDH1A1BTN3A1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068215-A1 | AZT DERIVATIVES EXHIBITING SPERMICIDAL AND ANTI-VIRAL ACTIVITY | Parker Hughes Institute (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999048902-A1 | AZT DERIVATIVES EXHIBITING SPERMICIDAL AND ANTI-VIRAL ACTIVITY | PARKER HUGHES INSTITUTE (US) | 1999-09-30 | — | — | WO | disclosed |