Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 6/20 | 0.44 |
| ▸ | NOS1 | P29475 | 6/20 | 0.44 |
| ▸ | NOS2 | P35228 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 3/20 | 0.39 |
| ▸ | HTR1B | P28222 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1F | P30939 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 3/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8033761 | 0.99 | NOS3 (0.46) | NOS3NOS1NOS2DRD2SLC6A4 | |
| SCHEMBL7802607 | 0.90 | HTR1D (0.47) | NOS3NOS1NOS2DRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8033531 | 0.88 | HTR1A (0.46) | NOS3NOS1NOS2DRD2SLC6A4 | |
| SCHEMBL7804925 | 0.80 | DRD2 (0.48) | DRD2SLC6A4HTR1DHTR1BHTR6 | |
| Hydrochloric Acid SCHEMBL8031557 | 0.79 | DRD2 (0.47) | DRD2SLC6A4HTR1DHTR1BHTR6 | |
| SCHEMBL7804939 | 0.78 | HTR1B (0.43) | DRD2HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL26408392 | 0.77 | NOS3 (0.49) | NOS3NOS1NOS2DRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8031585 | 0.77 | HTR1B (0.42) | DRD2HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL7804880 | 0.77 | HTR1D (0.46) | DRD2SLC6A4HTR1DHTR1BPDGFRB | |
| SCHEMBL30594683 | 0.76 | PRKCI (0.51) | NOS3NOS1NOS2DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |