Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR1F | P30939 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 4/20 | 0.42 |
| ▸ | NOS1 | P29475 | 4/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 12/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8033531 | 0.99 | HTR1A (0.46) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL7808749 | 0.90 | NOS3 (0.44) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| Hydrochloric Acid SCHEMBL8033761 | 0.88 | NOS3 (0.46) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL7808855 | 0.83 | KDM4C (0.36) | HTR1DHTR1BHTR1AHTR1FDRD2 | |
| Hydrochloric Acid SCHEMBL8031536 | 0.82 | KDM4C (0.35) | HTR1DHTR1BHTR1AHTR1FDRD2 | |
| SCHEMBL7798170 | 0.80 | DRD2 (0.39) | HTR1DHTR1BDRD2SLC6A4OPRM1 | |
| SCHEMBL7804156 | 0.80 | DRD2 (0.48) | HTR1DHTR1BDRD2SLC6A4 | |
| SCHEMBL7798189 | 0.80 | KMT2A (0.52) | NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL8033624 | 0.79 | DRD2 (0.47) | HTR1DHTR1BDRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8030850 | 0.79 | DRD2 (0.38) | DRD2SLC6A4OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046205-A | FOR TREATMENT OF VENOUS INSUFFICIENCY AND OF ASSOCIATED DISORDERS, AND ALSO IN THE TREATMENT OF MIGRAINE | ADIR ET COMPAGNIE (FR) | 2000-04-04 | — | — | US | claimed |
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |