Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | PRKACG | P22612 | 1/20 | 0.33 |
| ▸ | PRKACB | P22694 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26808310 | 0.82 | KMT2A (0.41) | KMT2AOPRM1OPRD1ALOX5 | |
| SCHEMBL3272500 | 0.81 | OPRM1 (0.41) | OPRM1 | |
| SCHEMBL7811749 | 0.81 | PIK3CD (0.39) | KMT2APIK3CDOPRM1ALOX5 | |
| SCHEMBL3024988 | 0.81 | PDE4A (0.44) | KMT2AOPRM1OPRD1ALOX5 | |
| SCHEMBL13439854 | 0.80 | PIK3CD (0.45) | KMT2APIK3CDOPRM1PRKACAPRKACG | |
| SCHEMBL3567445 | 0.80 | ALOX5 (0.43) | KMT2APIK3CDPRKACAPRKACGPRKACB | |
| SCHEMBL1598590 | 0.78 | KMT2A (0.41) | KMT2APIK3CDOPRM1PRKACAPRKACG | |
| SCHEMBL7808956 | 0.78 | MAP3K12 (0.32) | PIK3CDALOX5 | |
| SCHEMBL625294 | 0.77 | ICMT (0.44) | KMT2APIK3CDOPRM1 | |
| SCHEMBL1599547 | 0.77 | KMT2A (0.40) | KMT2APIK3CDOPRM1PRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787127-B1 | 5-LIPOXYGENASE INHIBITORS | PFIZER (US) | 2001-01-03 | — | — | EP | disclosed |
| US-6063928-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, CARDIOTONIC AGENTS | PFIZER INC (US) | 2000-05-16 | — | — | US | disclosed |
| US-5883106-A | 5-lipoxygenase inhibitors | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0787127-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1997-08-06 | — | — | EP | disclosed |
| WO-1996011911-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1996-04-25 | — | — | WO | disclosed |