Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.43 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.40 |
| ▸ | S100A10 | P60903 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811821 | 0.81 | ALOX5 (0.42) | ALOX5PIK3CDKMT2ACYP19A1 | |
| SCHEMBL3574382 | 0.81 | ALOX5 (0.46) | ALOX5PIK3CDKMT2A | |
| SCHEMBL3561984 | 0.81 | ALOX5 (0.43) | ALOX5PIK3CDKMT2AKDM4EALDH1A1 | |
| SCHEMBL7809060 | 0.80 | KMT2A (0.41) | ALOX5PIK3CDPRKACAPRKACGPRKACB | |
| SCHEMBL7892149 | 0.79 | ALOX5 (0.42) | ALOX5KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL332725 | 0.79 | ALOX5 (0.53) | ALOX5PIK3CDKMT2A | |
| SCHEMBL3572528 | 0.79 | ALOX5 (0.41) | ALOX5PIK3CDKMT2AMAOAMAOB | |
| SCHEMBL1599579 | 0.78 | ALOX5 (0.36) | ALOX5PIK3CDKMT2A | |
| SCHEMBL1599433 | 0.78 | ALOX5 (0.35) | ALOX5PIK3CDCYP19A1 | |
| SCHEMBL7807422 | 0.78 | ALOX5 (0.44) | ALOX5PIK3CDTSHRMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674811-B2 | 5-lipoxygenase inhibitors | RANBAXY LABORATORIES LIMITED (IN) | 2010-03-09 | — | — | US | disclosed |
| US-20080021080-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2008-01-24 | — | — | US | disclosed |
| EP-1834953-A1 | Tetrahydropyrane derivatives as 5-lipoxygenase inhibitors | Ranbaxy Laboratories Limited (IN) | 2007-09-19 | — | — | EP | disclosed |
| EP-1029865-B1 | Process for preparing 5-lipoxygenase inhibitors | PFIZER PROD INC (US) | 2004-04-28 | — | — | EP | disclosed |
| US-6194585-B1 | REACTING 4-(3-(4-(2-(ALKYL OR ARYL-IMIDAZOL-1-YL)-PHENYL SULFANYL)-PHENYL)-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID AMIDE WITH METHANESULFONIC ACID TO FORM CORRESPONDING METHANESULFONIC ACID | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1029865-A2 | Process and intermediates for preparing 5-lipoxygenase inhibitors | Pfizer Products Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021080-A1 | 5-LIPOXYGENASE INHIBITORS | ALOX5, ALOX15B, ALOX15 | ALOX5 1/4885ANXA2 492/4885S100A10 1810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.