Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 3/20 | 0.45 |
| ▸ | CTSS | P25774 | 3/20 | 0.45 |
| ▸ | CTSB | P07858 | 2/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.45 |
| ▸ | CTSD | P07339 | 2/20 | 0.43 |
| ▸ | TACR1 | P25103 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807985 | 0.91 | CTSD (0.56) | TRPM8CTSLCTSSCTSBCTSK | |
| SCHEMBL7807979 | 0.87 | TRPM8 (0.56) | TRPM8CTSLCTSSCTSBCTSK | |
| SCHEMBL8945567 | 0.85 | CTSD (0.53) | CTSLCTSSCTSBCTSKCTSD | |
| SCHEMBL7321385 | 0.83 | TRPM8 (0.55) | TRPM8CTSLCTSSCTSBCTSK | |
| SCHEMBL7428630 | 0.83 | TRPM8 (0.55) | TRPM8CTSLCTSSCTSBCTSK | |
| SCHEMBL7152790 | 0.81 | TRPM8 (0.54) | TRPM8CTSLCTSSCTSBCTSK | |
| SCHEMBL7320400 | 0.81 | TRPM8 (0.54) | TRPM8CTSLCTSSCTSBCTSK | |
| SCHEMBL9724730 | 0.81 | TRPM8 (0.53) | TRPM8CTSLCTSSCTSBCTSK | |
| SCHEMBL5704587 | 0.81 | TRPM8 (0.57) | TRPM8CTSLCTSSCTSBCTSK | |
| SCHEMBL8606837 | 0.80 | CMA1 (0.51) | TRPM8CTSLCTSSCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721449-B1 | INHIBITORS OF BETA-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMA INC (US) | 2001-12-19 | — | — | EP | disclosed |
| US-5977074-A | THERAPY FOR ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0721449-A1 | INHIBITORS OF $g(b)-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-17 | — | — | EP | disclosed |
| WO-1995009838-A1 | INHIBITORS OF β-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1995-04-13 | — | — | WO | disclosed |