Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.56 |
| ▸ | CTSD | P07339 | 3/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7809177 | 0.87 | TRPM8 (0.49) | TRPM8CTSDCTRB1CTSBCTSL | |
| SCHEMBL7428630 | 0.87 | TRPM8 (0.55) | TRPM8CTRB1CTSBCTSLCTSS | |
| SCHEMBL7321385 | 0.87 | TRPM8 (0.55) | TRPM8CTRB1CTSBCTSLCTSS | |
| SCHEMBL6556306 | 0.85 | ATM (0.54) | CTSBCTSLCTSSCTSKREN | |
| SCHEMBL6556305 | 0.85 | ATM (0.54) | CTSBCTSLCTSSCTSKREN | |
| SCHEMBL9724730 | 0.85 | TRPM8 (0.53) | TRPM8CTRB1CTSBCTSLCTSS | |
| SCHEMBL5704587 | 0.84 | TRPM8 (0.57) | TRPM8CTSDCTRB1CTSBCTSL | |
| SCHEMBL8736745 | 0.84 | CTSD (0.61) | TRPM8CTSDCTSSCTSKPSMB1 | |
| SCHEMBL9081107 | 0.83 | REN (0.49) | CTSBCTSLCTSSCTSKREN | |
| SCHEMBL7320400 | 0.83 | TRPM8 (0.54) | TRPM8CTRB1CTSBCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721449-B1 | INHIBITORS OF BETA-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMA INC (US) | 2001-12-19 | — | — | EP | disclosed |
| US-5977074-A | THERAPY FOR ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0721449-A1 | INHIBITORS OF $g(b)-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-17 | — | — | EP | disclosed |
| WO-1995009838-A1 | INHIBITORS OF β-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1995-04-13 | — | — | WO | disclosed |