Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.53 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | TACR1 | P25103 | 2/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321385 | 0.90 | TRPM8 (0.55) | TRPM8CTRB1CTSBCTSLTACR1 | |
| SCHEMBL7428630 | 0.90 | TRPM8 (0.55) | TRPM8CTRB1CTSBCTSLTACR1 | |
| SCHEMBL10431950 | 0.90 | CTSL (0.47) | TRPM8CTRB1CTSBCTSL | |
| SCHEMBL5704587 | 0.87 | TRPM8 (0.57) | TRPM8CTRB1CTSBCTSLTACR1 | |
| SCHEMBL7294855 | 0.87 | CTSK (0.52) | CTSBCTSLCTSSCTSK | |
| SCHEMBL7152790 | 0.86 | TRPM8 (0.54) | TRPM8CTRB1CTSBCTSLTACR1 | |
| SCHEMBL7320400 | 0.86 | TRPM8 (0.54) | TRPM8CTRB1CTSBCTSLTACR1 | |
| SCHEMBL7807979 | 0.85 | TRPM8 (0.56) | TRPM8CTRB1CTSBCTSLTACR1 | |
| SCHEMBL7268961 | 0.84 | TRPM8 (0.54) | TRPM8CTRB1CTSBCTSLTACR1 | |
| SCHEMBL7335755 | 0.83 | TRPM8 (0.53) | TRPM8CTRB1CTSBCTSLTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114927-A | Hypotensive agents and inhibiting renin | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0356595-A1 | Novel peptidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-07 | — | — | EP | disclosed |