Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TYMS | P04818 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CDC25B | P30305 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811086 | 0.88 | LMNA (0.50) | LMNAHPGDALDH1A1PKMKDM4E | |
| SCHEMBL7807528 | 0.85 | APP (0.52) | LMNAHPGDALDH1A1KDM4EMEN1 | |
| Dimethylamine SCHEMBL7814925 | 0.79 | LMNA (0.52) | LMNAHPGDALDH1A1KDM4EMEN1 | |
| SCHEMBL8923261 | 0.78 | KDM4E (0.50) | KDM4EMEN1CYP2C9BLMKMT2A | |
| SCHEMBL16627873 | 0.75 | IDH1 (0.46) | HPGDALDH1A1KDM4EMEN1CYP2C9 | |
| SCHEMBL8783757 | 0.72 | KDM4E (0.62) | KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL7811152 | 0.70 | ACHE (0.51) | LMNAHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9390802 | 0.69 | LMNA (1.00) | LMNAHPGDALDH1A1PKMKDM4E | |
| SCHEMBL9086944 | 0.68 | LMNA (0.70) | LMNAHPGDALDH1A1KDM4EMEN1 | |
| SCHEMBL7350621 | 0.68 | DAO (0.65) | LMNAHPGDALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644878-B1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-09-12 | — | — | EP | disclosed |
| US-5712272-A | TREATMENT OF NEUROLOGICAL DISORDERS WITH BENZ(B)AZEPINE COMPOUNDS | ZENECA LIMITED (GB) | 1998-01-27 | — | — | US | disclosed |
| US-5654295-A | NEUROLOGICAL DISORDERS; BENZ(B0AZEPINE COMPOUNDS | ZENECA LIMITED (GB) | 1997-08-05 | — | — | US | disclosed |
| US-5492905-A | NERVOUS SYSTEM DISORDERS | ZENECA LIMITED (GB) | 1996-02-20 | — | — | US | disclosed |
| WO-1993025534-A1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 1993-12-23 | — | — | WO | disclosed |