Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7802928 | 0.78 | LMNA (0.45) | ALDH1A1LMNAHPGDHSD17B10TSHR | |
| SCHEMBL8173934 | 0.72 | SIGMAR1 (0.70) | ALDH1A1DRD4DRD2DRD3TSHR | |
| Hydrochloric Acid SCHEMBL27955450 | 0.71 | SIGMAR1 (0.61) | ALDH1A1DRD4DRD2DRD3KDM4E | |
| SCHEMBL8168486 | 0.71 | SIGMAR1 (0.65) | ALDH1A1DRD4DRD2DRD3SIGMAR1 | |
| SCHEMBL1783455 | 0.70 | DRD4 (0.57) | ALDH1A1DRD4DRD2DRD3LMNA | |
| Hydrochloric Acid SCHEMBL11032993 | 0.70 | DRD2 (0.57) | ACHEALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL7809286 | 0.70 | LMNA (0.52) | ALDH1A1LMNAHPGDHSD17B10KDM4E | |
| SCHEMBL8311608 | 0.70 | MAPT (0.62) | ALDH1A1DRD4DRD2DRD3TRPC5 | |
| SCHEMBL11164060 | 0.69 | DRD4 (0.55) | ALDH1A1DRD4DRD2DRD3LMNA | |
| SCHEMBL27470403 | 0.69 | CYP3A4 (0.71) | ALDH1A1DRD3CHRM1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644878-B1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-09-12 | — | — | EP | claimed |
| US-5492905-A | NERVOUS SYSTEM DISORDERS | ZENECA LIMITED (GB) | 1996-02-20 | — | — | US | claimed |