SCHEMBL7809476

SCHEMBL7809476

COS(=O)(=O)Oc1c(C(C)=O)c(=O)[nH]c2c(C#N)cccc12

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 1/20 0.34
ALDH1A1 P00352 4/20 0.34
KDM4E B2RXH2 4/20 0.34
FBP1 P09467 1/20 0.32
PDE4B Q07343 1/20 0.32
GALR3 O60755 1/20 0.31
RAB9A P51151 1/20 0.31
MMP13 P45452 1/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
HPGD P15428 2/20 0.31
GLA P06280 1/20 0.31
GAA P10253 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
LMNA P02545 1/20 0.31
POLB P06746 1/20 0.31
TSHR P16473 1/20 0.31
FASN P49327 1/20 0.31
ELANE P08246 2/20 0.30
CA12 O43570 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7809496 0.84 KDM4E (0.43) ALDH1A1KDM4EMEN1KMT2AHPGD
SCHEMBL7804023 0.83 TUBB4A (0.39) ALDH1A1KDM4E
SCHEMBL7813787 0.83 TUBB4A (0.39) PLA2G7ALDH1A1KDM4EMEN1KMT2A
SCHEMBL7809663 0.82 DAO (0.38) PLA2G7ALDH1A1KDM4EMEN1KMT2A
SCHEMBL7803962 0.81 DAO (0.37) PLA2G7ALDH1A1KDM4E
SCHEMBL7817118 0.81 CAPN1 (0.42) PLA2G7ALDH1A1KDM4EFBP1MEN1
SCHEMBL7809479 0.81 KDM4E (0.36) PLA2G7ALDH1A1KDM4EGALR3RAB9A
SCHEMBL7809532 0.80 FEN1 (0.40) ALDH1A1KDM4ERAB9AMEN1KMT2A
SCHEMBL7816993 0.74 KDM4E (0.41) PLA2G7ALDH1A1KDM4EGALR3RAB9A
SCHEMBL7811062 0.71 KDM4E (0.35) ALDH1A1KDM4EGAACA9CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0533882-B1 2-QUINOLINONE DERIVATIVES, METHODS FOR PREPARING THE SAME AND FUNGICIDES AND INSECTICIDES INCLUDING THEM KOREA RES INST CHEM TECH (KR) 2001-02-07 EP disclosed
US-5430153-A Insecticides, fungicides KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1995-07-04 US disclosed
EP-0533882-A1 2-QUINOLINONE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1993-03-31 EP disclosed
WO-1992017452-A1 2-QUINOLINONE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1992-10-15 WO disclosed