SCHEMBL7809479

SCHEMBL7809479

CSOc1c(C(C)=O)c(=O)[nH]c2c(C#N)cccc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.36
ELANE P08246 2/20 0.33
ALDH1A1 P00352 4/20 0.33
GALR3 O60755 2/20 0.33
RAB9A P51151 1/20 0.33
HPGD P15428 2/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
LMNA P02545 1/20 0.32
POLB P06746 1/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
PLA2G7 Q13093 1/20 0.32
MCL1 Q07820 1/20 0.31
GAA P10253 2/20 0.30
MMP13 P45452 1/20 0.30
GLA P06280 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7809500 0.83 KDM4E (0.45) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL7804026 0.81 RXFP1 (0.45) KDM4ELMNA
SCHEMBL7813789 0.81 FEN1 (0.39) KDM4EALDH1A1KMT2ALMNA
SCHEMBL7816993 0.81 KDM4E (0.41) KDM4EELANEALDH1A1GALR3RAB9A
SCHEMBL7809669 0.81 DAO (0.40) KDM4EALDH1A1RAB9AHPGDMEN1
SCHEMBL7809476 0.81 PLA2G7 (0.34) KDM4EELANEALDH1A1GALR3RAB9A
SCHEMBL7817120 0.80 CAPN1 (0.44) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL7809535 0.79 FEN1 (0.42) KDM4EALDH1A1RAB9AHPGDMEN1
SCHEMBL497316 0.76 KDM4E (0.58) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL7811064 0.70 KDM4E (0.39) KDM4EALDH1A1HSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0533882-B1 2-QUINOLINONE DERIVATIVES, METHODS FOR PREPARING THE SAME AND FUNGICIDES AND INSECTICIDES INCLUDING THEM KOREA RES INST CHEM TECH (KR) 2001-02-07 EP disclosed
US-5430153-A Insecticides, fungicides KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1995-07-04 US disclosed
EP-0533882-A1 2-QUINOLINONE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1993-03-31 EP disclosed
WO-1992017452-A1 2-QUINOLINONE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1992-10-15 WO disclosed