Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.42 |
| ▸ | EBP | Q15125 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130837 | 0.70 | SIGMAR1 (0.47) | MAPK1SMN1; SMN2SIGMAR1EBPCHRM2 | |
| SCHEMBL14430488 | 0.70 | MAPK1 (0.58) | MAPK1SMN1; SMN2KDM1ASIGMAR1EBP | |
| SCHEMBL7811146 | 0.68 | MAPK1 (0.40) | MAPK1SMN1; SMN2SIGMAR1EBPCHRM2 | |
| SCHEMBL5200044 | 0.68 | MAPK1 (0.64) | MAPK1SMN1; SMN2KDM1ASIGMAR1CHRM2 | |
| SCHEMBL14430497 | 0.68 | MAPK1 (0.56) | MAPK1SMN1; SMN2KDM1ASIGMAR1L3MBTL1 | |
| SCHEMBL19505650 | 0.67 | LMNA (0.63) | MAPK1SMN1; SMN2KDM1ASIGMAR1EBP | |
| SCHEMBL9044216 | 0.67 | MAPK1 (0.69) | MAPK1SMN1; SMN2KDM1ASIGMAR1CHRM2 | |
| SCHEMBL10409949 | 0.67 | MAPK1 (0.79) | MAPK1SMN1; SMN2KDM1ACHRM2CHRM4 | |
| SCHEMBL11521605 | 0.67 | MAPK1 (0.79) | MAPK1SMN1; SMN2KDM1ACHRM2CHRM4 | |
| SCHEMBL8709456 | 0.66 | MAPK1 (0.72) | MAPK1SMN1; SMN2KDM1ACHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733043-B1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORP (US) | 2001-06-20 | — | — | EP | disclosed |
| EP-0733043-A1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORPORATION (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5464840-A | Pharmaceuticals to inhibit tumor necrosis factor-alpha and to treat septic shock, inflammation and allergic disease | SCHERING CORPORATION (US) | 1995-11-07 | — | — | US | disclosed |
| WO-1995015949-A1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORPORATION (US) | 1995-06-15 | — | — | WO | disclosed |