Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.39 |
| ▸ | EBP | Q15125 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7809704 | 0.82 | MAPK1 (0.38) | MAPK1SMN1; SMN2SIGMAR1CHRM2ADRA2A | |
| SCHEMBL21130837 | 0.70 | SIGMAR1 (0.47) | MAPK1SMN1; SMN2SIGMAR1EBPCHRM2 | |
| SCHEMBL22179399 | 0.68 | SIGMAR1 (0.33) | SIGMAR1 | |
| SCHEMBL7809995 | 0.68 | MAPK1 (0.60) | MAPK1SMN1; SMN2SIGMAR1EBPCHRM2 | |
| SCHEMBL7782464 | 0.65 | ESR2 (0.48) | SIGMAR1EBPMAOB | |
| SCHEMBL19505650 | 0.65 | LMNA (0.63) | MAPK1SMN1; SMN2SIGMAR1EBPCHRM2 | |
| SCHEMBL7817126 | 0.64 | NOTUM (0.40) | MAPK1SMN1; SMN2SIGMAR1 | |
| Ammonia Solution, Strong SCHEMBL27550700 | 0.63 | ESR2 (0.47) | SIGMAR1EBPMAOB | |
| SCHEMBL7813352 | 0.63 | SIGMAR1 (0.44) | MAPK1SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL8506366 | 0.62 | HTR2A (0.46) | MAPK1SMN1; SMN2SIGMAR1EBPCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733043-B1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORP (US) | 2001-06-20 | — | — | EP | disclosed |
| EP-0733043-A1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORPORATION (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5464840-A | Pharmaceuticals to inhibit tumor necrosis factor-alpha and to treat septic shock, inflammation and allergic disease | SCHERING CORPORATION (US) | 1995-11-07 | — | — | US | disclosed |
| WO-1995015949-A1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORPORATION (US) | 1995-06-15 | — | — | WO | disclosed |