Aprobarbital

Aprobarbital

SCHEMBL78101

C=CCC1(C(C)C)C(=O)NC(=O)NC1=O

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 1/20 0.67
CYP3A4 P08684 2/20 0.43
NR1I2 O75469 1/20 0.43
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 1/20 0.43
GABRB3 P28472 1/20 0.43
OPRD1 P41143 1/20 0.43
GABRA2 P47869 1/20 0.43
GABRB2 P47870 1/20 0.43
LMNA P02545 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aprobarbital SCHEMBL21807710 0.98 MMP9 (0.65) MMP9CYP3A4NR1I2KDM4EALDH1A1
Talbutal SCHEMBL4263344 0.90 MMP9 (0.69) MMP9CYP3A4NR1I2KDM4EALDH1A1
SCHEMBL10582779 0.86 MMP9 (0.51) MMP9CYP3A4NR1I2KDM4EALDH1A1
Aprobarbital SCHEMBL15543386 0.84 MMP9 (0.51) MMP9CYP3A4NR1I2KDM4EALDH1A1
Talbutal SCHEMBL122147 0.83 MMP9 (0.76) MMP9CYP3A4NR1I2KDM4EALDH1A1
Secobarbital SCHEMBL80734 0.80 MMP9 (1.00) MMP9CYP3A4NR1I2KDM4EALDH1A1
Secobarbital SCHEMBL41181 0.80 MMP9 (1.00) MMP9CYP3A4NR1I2KDM4EALDH1A1
Secobarbital SCHEMBL80735 0.80 MMP9 (1.00) MMP9CYP3A4NR1I2KDM4EALDH1A1
Secobarbital SCHEMBL8085730 0.80 MMP9 (1.00) MMP9CYP3A4NR1I2KDM4EALDH1A1
Secobarbital SCHEMBL41182 0.79 MMP9 (0.97) MMP9CYP3A4NR1I2KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4994 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3441087-B1 METHODS OF TREATING CHRONIC PAIN TEVA PHARMACEUTICALS INT GMBH (CH) 2025-02-19 EP claimed
US-12161695-B2 GABA A receptor agonists for treatment of disorders influenced by dysfunction BETA cells DIAMYD MEDICAL AB (SE) 2024-12-10 US claimed
CN-114572330-B Electric vehicle intelligent vehicle-mounted terminal based on millimeter wave radar 深圳飞亮智能科技有限公司 2024-03-08 CN claimed
US-11839615-B2 Compounds and methods for treating addiction and related disorders ASTROCYTE PHARMACEUTICALS, INC. (US) 2023-12-12 US claimed
CN-116151848-B Gas cylinder quality safety traceability system based on Internet of things 深圳市普燃计算机软件科技有限公司 2023-08-11 CN claimed
CN-115457702-B New energy automobile fills electric pile based on cloud calculates 湖北盛泓电力技术开发有限公司 2023-04-21 CN claimed
EP-3891505-B1 A METHOD FOR MEASURING A CONCENTRATION OF A BIOMARKER/ANALYTE IN BLOOD FROM MAMMALS REDHOTDIAGNOSTICS AB (SE) 2022-11-30 EP claimed
CN-109903284-B HER2 immunohistochemical image automatic discrimination method and system 武汉大学 2022-07-05 CN claimed
US-20220187304-A1 A Method for Measuring a Concentration of a Biomarker-Analyte In Blood from Mammals REDHOT DIAGNOSTICS AB (SE) 2022-06-16 US claimed
CN-114572330-A Electric motor car intelligence vehicle mounted terminal based on millimeter wave radar 深圳飞亮智能科技有限公司 2022-06-03 CN claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-0983060-A1 SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME IMARX PHARMACEUTICAL CORP. (US) 2000-03-08 EP claimed
WO-2000001805-A1 CELLS AND ANIMALS DEFICIENT IN PROTEIN KINASE C EPSILON MESSING ROBERT O (US) 2000-01-13 WO claimed
WO-1999042111-A1 HIGH-ENERGY CYCLODEXTRIN COMPLEXES CYCLOPS, EHF. (IS) 1999-08-26 WO claimed
WO-1998051282-A1 SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME IMARX PHARMACEUTICAL CORP. (US) 1998-11-19 WO claimed
US-5770222-A Therapeutic drug delivery systems IMARX PHARMACEUTICAL CORP. (US) 1998-06-23 US claimed
US-5585243-A SEPARATELY INCUBATING HUMAN PLATELETS WITH BLOOD SAMPLE ANDREAGENT DRUG SOLUTION TO FORM COMPLEXES, DETERMINING AMOUNT OF BOUND ANTIBODY THE BLOOD CENTER OF SOUTHEASTERN WISCONSIN, INC. (US) 1996-12-17 US claimed
WO-1995008116-A1 METHOD OF DETECTING CYTOPENIA THAT IS MEDIATED BY DRUG-DEPENDENT ANTIBODY BINDING TO BLOOD CELLS THE BLOOD CENTER OF SOUTHEASTERN WISCONSIN, INC. (US) 1995-03-23 WO claimed
US-4557934-A ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE THE PROCTER & GAMBLE COMPANY (US) 1985-12-10 US claimed
US-RE29875-E THEOPHYLLINE SOLUBILIZED BY GLYCERYL GUAIACOLATE, POTASSIUM GUAIACOL SULFONATE OR GUAIACOL MEAD JOHNSON & COMPANY (US) 1979-01-02 US claimed