Secobarbital

Secobarbital

SCHEMBL80735

C=CCC1([C@@H](C)CCC)C(=O)NC(=O)NC1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ

The experimentally established mechanism targets of Secobarbital. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GABRB3 known ✓ P28472 1/20 0.67
GABRA2 known ✓ P47869 1/20 0.67
GABRB2 known ✓ P47870 1/20 0.67
MMP9 P14780 1/20 1.00
CYP3A4 P08684 3/20 0.67
KDM4E B2RXH2 1/20 0.67
ALDH1A1 P00352 1/20 0.67
OPRD1 P41143 1/20 0.67
NR1I2 O75469 1/20 0.62
LMNA P02545 4/20 0.54
RECQL P46063 1/20 0.36
CYP19A1 P11511 1/20 0.31
POLB P06746 1/20 0.30
PKM P14618 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Secobarbital SCHEMBL41181 1.00 MMP9 (1.00) MMP9CYP3A4KDM4EALDH1A1GABRB3
Secobarbital SCHEMBL8085730 1.00 MMP9 (1.00) MMP9CYP3A4KDM4EALDH1A1GABRB3
Secobarbital SCHEMBL80734 1.00 MMP9 (1.00) MMP9CYP3A4KDM4EALDH1A1GABRB3
Secobarbital SCHEMBL7599361 0.98 MMP9 (0.97) MMP9CYP3A4KDM4EALDH1A1GABRB3
Secobarbital SCHEMBL41182 0.98 MMP9 (0.97) MMP9CYP3A4KDM4EALDH1A1GABRB3
Secobarbital SCHEMBL614906 0.98 MMP9 (0.97) MMP9CYP3A4KDM4EALDH1A1GABRB3
Secobarbital SCHEMBL28198576 0.97 MMP9 (0.94) MMP9CYP3A4KDM4EALDH1A1GABRB3
Secobarbital SCHEMBL7778384 0.91 MMP9 (0.83) MMP9CYP3A4KDM4EALDH1A1GABRB3
Thiamylal SCHEMBL1666144 0.89 MMP9 (0.79) MMP9CYP3A4KDM4EALDH1A1GABRB3
Thiamylal SCHEMBL548050 0.89 MMP9 (0.79) MMP9CYP3A4KDM4EALDH1A1GABRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 11486 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4719552-A1 INDUCTION OF GENERAL ANESTHESIA IN ADULTS UNDERGOING ELECTIVE SURGERY Xizang Haisco Pharmaceutical Co., Ltd. (CN) 2026-04-08 EP claimed
US-20260041939-A1 METHODS FOR THE TREATMENT OF HYPERTENSION VIA TRANSCRANIAL-FOCUSED-ULTRASOUND SUNNYBROOK RES INST (CA) 2026-02-12 US claimed
EP-3507371-B1 COMPOSITIONS FOR TREATING DISEASES AND DISORDERS OF THE NERVOUS SYSTEM UNIV RUTGERS (US) 2026-01-28 EP claimed
EP-4630446-A1 ENGINEERED SWITCHES FOR IMMUNE CELL ACTIVITY AND METHODS OF USE THEREOF Dynamic Cell Therapies, Inc. (US) 2025-10-15 EP claimed
EP-4630043-A1 IMMUNE-ACTIVATING COMPLEXES Dynamic Cell Therapies, Inc. (US) 2025-10-15 EP claimed
EP-4622640-A1 COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF Brightseed, Inc. (US) 2025-10-01 EP claimed
US-20250295671-A1 Hazardous Agent Injection System ANTARES PHARMA, INC. (US) 2025-09-25 US claimed
US-20250281451-A1 COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF BRIGHTSEED, INC. 2025-09-11 US claimed
US-12383743-B2 Treatment of addiction and dependency TACA JR ARTURO C (US) 2025-08-12 US claimed
US-20250249002-A1 PHARMACEUTICAL COMPOSITION FOR TOPICAL WOUND TREATMENT CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECN (AR) 2025-08-07 US claimed
US-4557934-A ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE THE PROCTER & GAMBLE COMPANY (US) 1985-12-10 US claimed
US-4466953-A Polymeric diffusion matrix KEY PHARMACEUTICALS, INC. (US) 1984-08-21 US claimed
US-4244939-A RADIOIMMUNOASSAY BAXTER TRAVENOL LABORATORIES, INC. (US) 1981-01-13 US claimed
US-4175119-A Composition and method to prevent accidental and intentional overdosage with psychoactive drugs PORTER GARRY L 1979-11-20 US claimed
US-4168308-A Composition for enhancing the administration of pharmacologically active agents APOTEKSVARUCENTRALEN VITRUM AB (SE) 1979-09-18 US claimed
US-4126684-A 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE CIBA-GEIGY CORPORATION (US) 1978-11-21 US claimed
US-4107153-A Heat-resistant thermosetting polyimide resin TOSHIBA CHEMICAL PRODUCTS CO., LTD. (JP) 1978-08-15 US claimed
US-4097545-A Heat-resistant thermosetting polyimide resin with bis-phenol-epichlorohydrin reaction product TOSHIBA CHEMICAL PRODUCTS CO. LTD. (JA) 1978-06-27 US claimed
US-4036823-A Barbituric acid antigenic conjugates, their preparation, antibodies and use BIOLOGICAL DEVELOPMENTS, INC. (US) 1977-07-19 US claimed
US-3952091-A Simultaneous multiple radioimmunoassay HOFFMANN-LA ROCHE INC. (US) 1976-04-20 US claimed