Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Talbutal. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.47 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.47 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Talbutal SCHEMBL4263344 | 0.95 | MMP9 (0.69) | MMP9CYP3A4KDM4EALDH1A1GABRB3 | |
| Secobarbital SCHEMBL7778384 | 0.88 | MMP9 (0.83) | MMP9CYP3A4KDM4EALDH1A1GABRB3 | |
| SCHEMBL10582774 | 0.88 | MMP9 (0.59) | MMP9CYP3A4KDM4EALDH1A1GABRB3 | |
| Secobarbital SCHEMBL80735 | 0.86 | MMP9 (1.00) | MMP9CYP3A4KDM4EALDH1A1GABRB3 | |
| Secobarbital SCHEMBL41181 | 0.86 | MMP9 (1.00) | MMP9CYP3A4KDM4EALDH1A1GABRB3 | |
| Secobarbital SCHEMBL80734 | 0.86 | MMP9 (1.00) | MMP9CYP3A4KDM4EALDH1A1GABRB3 | |
| Secobarbital SCHEMBL8085730 | 0.86 | MMP9 (1.00) | MMP9CYP3A4KDM4EALDH1A1GABRB3 | |
| Vinylbital SCHEMBL13724735 | 0.86 | MMP9 (0.74) | MMP9CYP3A4KDM4EALDH1A1GABRB3 | |
| Secobarbital SCHEMBL7599361 | 0.85 | MMP9 (0.97) | MMP9CYP3A4KDM4EALDH1A1GABRB3 | |
| Secobarbital SCHEMBL41182 | 0.85 | MMP9 (0.97) | MMP9CYP3A4KDM4EALDH1A1GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3642 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3441087-B1 | METHODS OF TREATING CHRONIC PAIN | TEVA PHARMACEUTICALS INT GMBH (CH) | 2025-02-19 | — | — | EP | claimed |
| WO-2025003534-A1 | SYSTEM FOR SELECTING SPERMATOZOA | CREA MEDICINA DE LA REPRODUCCION, S.L. (ES) | 2025-01-02 | — | — | WO | claimed |
| WO-2023135346-A9 | METHOD AND SYSTEM FOR PREDICTING GLUCOSE VALUES AND GENERATING HYPOGLYCAEMIA AND HYPERGLYCAEMIA WARNINGS | UNIVERSIDAD COMPLUTENSE DE MADRID (ES) | 2023-09-07 | — | — | WO | claimed |
| WO-2023115184-A1 | NON-INVASIVE METHOD FOR SCREENING LIQUID IMPLANTS IN DEEP ANATOMICAL PLANES | CADORE MAFALDO RODRIGO (BR) | 2023-06-29 | — | — | WO | claimed |
| WO-2023012390-A1 | A SENSOR AND A METHOD FOR DETECTING THE DIRECTION OF LIGHT | UNIVERSITAT POLITECNICA DE CATALUNYA (ES) | 2023-02-09 | — | — | WO | claimed |
| WO-2022079337-A1 | SYSTEM FOR DETECTING DISORDERED SPACES FOR A CLEANING AND/OR DISINFECTING ROBOT AND ASSOCIATED METHOD | CECOTEC RESEARCH AND DEVELOPMENT, S.L. (ES) | 2022-04-21 | — | — | WO | claimed |
| EP-3810184-A2 | METHODS OF TREATING OR INHIBITING ONSET OF HUNTINGTON'S DISEASE | University of Rochester (US) | 2021-04-28 | — | — | EP | claimed |
| WO-2021054927-A2 | GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS | SOUTH DAKOTA BOARD OF REGENTS (US) | 2021-03-25 | — | — | WO | claimed |
| US-20210060123-A1 | THERAPEUTIC USE OF P75NTR NEUROTROPHIN BINDING PROTEIN | LEVICEPT LTD (GB) | 2021-03-04 | — | — | US | claimed |
| US-20200345722-A1 | ABUSE-DETERRENT DRUG FORMULATIONS | COLLEGIUM PHARMACEUTICAL INC (US) | 2020-11-05 | — | — | US | claimed |
| WO-2000071109-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING S-(+) -DESMETHYLSELEGILINE FOR THE TREATMENT OF WITHDRAWAL | SOMERSET PHARMACEUTICALS, INC. (US) | 2000-11-30 | — | — | WO | claimed |
| WO-2000048636-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2000-08-24 | — | — | WO | claimed |
| EP-0983060-A1 | SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME | IMARX PHARMACEUTICAL CORP. (US) | 2000-03-08 | — | — | EP | claimed |
| WO-2000001805-A1 | CELLS AND ANIMALS DEFICIENT IN PROTEIN KINASE C EPSILON | MESSING ROBERT O (US) | 2000-01-13 | — | — | WO | claimed |
| WO-1998051282-A1 | SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME | IMARX PHARMACEUTICAL CORP. (US) | 1998-11-19 | — | — | WO | claimed |
| US-5770222-A | Therapeutic drug delivery systems | IMARX PHARMACEUTICAL CORP. (US) | 1998-06-23 | — | — | US | claimed |
| US-5654281-A | Inhibiting the development of tolerance to and/or dependence on an addictive substance | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1997-08-05 | — | — | US | claimed |
| EP-0608893-A1 | Inhibiting the development of tolerance to and/or dependence on an additive substance | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-08-03 | — | — | EP | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| US-4126684-A | 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE | CIBA-GEIGY CORPORATION (US) | 1978-11-21 | — | — | US | claimed |