Trifluoromethanesulfonic Acid

Trifluoromethanesulfonic Acid

SCHEMBL7811066

O=C1C=C(c2cc3ccccc3[nH]2)C(=O)N1.O=S(=O)(O)C(F)(F)F

nearest known ligand 0.40

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 2/20 0.40
CHEK1 O14757 1/20 0.40
CA2 P00918 2/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA9 Q16790 1/20 0.39
RAB9A P51151 3/20 0.38
NPC1 O15118 2/20 0.38
PRKD3 O94806 4/20 0.36
PRKCG P05129 4/20 0.36
PRKCB P05771 4/20 0.36
PRKCA P17252 4/20 0.36
PRKCH P24723 4/20 0.36
PRKCI P41743 4/20 0.36
PRKCE Q02156 4/20 0.36
PRKCQ Q04759 4/20 0.36
PRKCZ Q05513 4/20 0.36
PRKCD Q05655 4/20 0.36
PRKD1 Q15139 4/20 0.36
PRKACA P17612 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL856332 0.87 KDR (0.51) KDRCHEK1CA2CA12CA1
SCHEMBL29900484 0.87 KDR (0.51) KDRCHEK1CA2CA12CA1
Aniline SCHEMBL27928992 0.79 RAB9A (0.45) KDRCHEK1CA2CA12CA1
Imidazole SCHEMBL5232078 0.74 CYP19A1 (0.40) KDRCHEK1CA2CA12CA1
Trifluoromethanesulfonic Acid SCHEMBL2480378 0.69 CA12 (0.67) CA2CA12CA1CA9DAO
SCHEMBL29415921 0.68 PRKD3 (0.62) KDRCHEK1CA2CA12CA1
SCHEMBL78989 0.68 PRKD3 (0.62) KDRCHEK1CA2CA12CA1
SCHEMBL3959789 0.67 PRKD3 (0.61) KDRCHEK1CA2CA12CA1
SCHEMBL5454930 0.66 KDR (0.51) KDRCHEK1CA2CA12CA1
Anthracene SCHEMBL27569591 0.66 PTPN1 (0.43) CA2CA1CA9KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888339-A4 SYNTHESIS OF INDOLYLMALEIMIDES LILLY CO ELI (US) 2001-02-28 EP disclosed
US-6037475-A REACTING OPTIONALLY SUBSTITUTED, N-PROTECTED INDOL-3-YL-ACETAMIDE WITH AN ALKYL OXALATE AND A STRONG ORGANIC BASE IN A POLAR APROTIC SOLVENT FORMING OPTIONALLY SUBSTITUTED 4-(INDOL-3-YL)-3-HYDROXY PYRROLE-2,5-DIONE ELI LILLY & COMPANY (US) 2000-03-14 US disclosed
US-5919946-A REACTING AN ACTIVATED MALEIMIDE WITH AN ORGANOMETALLIC-3-INDOLE IN PRESENCE OF A PALLADIUM TRANSITION METAL CATALYST ELI LILLY AND COMPANY (US) 1999-07-06 US disclosed
US-5859261-A PROTEIN KINASE INHIBITORS ELI LILLY AND COMPANY (US) 1999-01-12 US disclosed
EP-0888339-A1 SYNTHESIS OF INDOLYLMALEIMIDES ELI LILLY AND COMPANY (US) 1999-01-07 EP disclosed
WO-1997034890-A1 SYNTHESIS OF INDOLYLMALEIMIDES ELI LILLY AND COMPANY (US) 1997-09-25 WO disclosed