Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.44 |
| ▸ | PRKCG | P05129 | 4/20 | 0.44 |
| ▸ | PRKCB | P05771 | 4/20 | 0.44 |
| ▸ | PRKCA | P17252 | 4/20 | 0.44 |
| ▸ | PRKCH | P24723 | 4/20 | 0.44 |
| ▸ | PRKCI | P41743 | 4/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29900484 | 1.00 | KDR (0.51) | KDRCHEK1RAB9ANPC1KDM4E | |
| Aniline SCHEMBL27928992 | 0.91 | RAB9A (0.45) | KDRCHEK1RAB9ANPC1KDM4E | |
| Trifluoromethanesulfonic Acid SCHEMBL7811066 | 0.87 | KDR (0.40) | KDRCHEK1RAB9ANPC1KDM4E | |
| Imidazole SCHEMBL5232078 | 0.85 | CYP19A1 (0.40) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL29415921 | 0.79 | PRKD3 (0.62) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL78989 | 0.79 | PRKD3 (0.62) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL3959789 | 0.77 | PRKD3 (0.61) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL5454930 | 0.73 | KDR (0.51) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL1158440 | 0.73 | KDR (0.51) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL31055001 | 0.73 | KDR (0.51) | KDRCHEK1RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 412 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112575449-B | Polypropylene non-woven fabric with antibacterial property and preparation method thereof | 广州市新君发无纺布制品包装材料有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-112575449-A | Polypropylene non-woven fabric with antibacterial property and preparation method thereof | 广州市新君发无纺布制品包装材料有限公司 | 2021-03-30 | — | — | CN | claimed |
| US-20200385685-A1 | ROBUST DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS INTO ENDOTHELIAL CELLS USING TRANSCRIPTION FACTOR ETV2 | CHILDREN'S MEDICAL CENTER CORPORATION | 2020-12-10 | — | — | US | claimed |
| CN-106188007-B | A kind of 3- piperidyls -4- indolylmaleimides class compounds and its preparation and application | 东华大学 | 2018-08-14 | — | — | CN | claimed |
| CN-108264503-A | A kind of preparation method of 3- Indolylmaleimide compounds | 东华大学 | 2018-07-10 | — | — | CN | claimed |
| CN-106188007-A | A kind of 3 piperidyl 4 indolylmaleimides compounds and preparation thereof and application | 东华大学 | 2016-12-07 | — | — | CN | claimed |
| CN-105153126-A | Preparation method of bisindolyl maleimide compounds | NAT UNIV DONG HWA | 2015-12-16 | — | — | CN | claimed |
| CN-103998444-A | Adhesive agent | CANCER THERAPEUTICS CRC PTY LTD | 2014-08-20 | — | — | CN | claimed |
| CN-101671329-B | Indolylmaleimide compound substituted with 3-amino alcohol, preparation method and application thereof | UNIV DONGHUA | 2012-11-07 | — | — | CN | claimed |
| CN-101671329-A | Indolylmaleimide compound substituted with 3-amino alcohol, preparation method and application thereof | UNIV DONGHUA | 2010-03-17 | — | — | CN | claimed |
| WO-2004083202-A1 | A PROCESS FOR THE PREPARATION OF INDOLYMALEIMIDES | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-09-30 | — | — | WO | claimed |
| EP-1441772-A2 | POLYMER CONJUGATES OF PROTEIN KINASE C INHIBITORS | Nektar Therapeutics Al, Corporation (US) | 2004-08-04 | — | — | EP | claimed |
| US-20030143185-A1 | Polymer conjugates of protein kinase C inhibitors | SHEARWATER CORPORATION | 2003-07-31 | — | — | US | claimed |
| WO-2003037384-A2 | POLYMER CONJUGATES OF PROTEIN KINASE C INHIBITORS | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2003-05-08 | — | — | WO | claimed |
| EP-1224932-A1 | DRUGS INHIBITING CELL DEATH | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 2002-07-24 | — | — | EP | claimed |
| EP-0888339-A4 | SYNTHESIS OF INDOLYLMALEIMIDES | LILLY CO ELI (US) | 2001-02-28 | — | — | EP | claimed |
| US-5919946-A | REACTING AN ACTIVATED MALEIMIDE WITH AN ORGANOMETALLIC-3-INDOLE IN PRESENCE OF A PALLADIUM TRANSITION METAL CATALYST | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | claimed |
| US-5859261-A | PROTEIN KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1999-01-12 | — | — | US | claimed |
| EP-0888339-A1 | SYNTHESIS OF INDOLYLMALEIMIDES | ELI LILLY AND COMPANY (US) | 1999-01-07 | — | — | EP | claimed |
| WO-1997034890-A1 | SYNTHESIS OF INDOLYLMALEIMIDES | ELI LILLY AND COMPANY (US) | 1997-09-25 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030143185-A1 | Polymer conjugates of protein kinase C inhibitors | PRKCH, PRKCI, PRKCA | KDR 1868/4885CHEK1 503/4885RAB9A 3147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.