Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3508656 | 0.89 | PARP1 (0.46) | LMNAPARP1DRD3 | |
| SCHEMBL7802441 | 0.85 | LMNA (0.53) | LMNAPARP1DRD3 | |
| SCHEMBL9137176 | 0.84 | ALOX5 (0.47) | ALOX5ALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL332753 | 0.83 | ALOX5 (0.50) | ALOX5ALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL2702973 | 0.83 | ALOX5 (0.50) | ALOX5ALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL19710855 | 0.83 | HDAC4 (0.51) | ALOX5ALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL2703559 | 0.82 | ALDH1A1 (0.58) | ALOX5ALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL27078112 | 0.81 | CYP2C19 (0.45) | ALOX5ALDH1A1LMNATSHRDRD3 | |
| SCHEMBL29731283 | 0.81 | CYP2C19 (0.45) | ALOX5ALDH1A1LMNATSHRDRD3 | |
| SCHEMBL19701993 | 0.80 | ALOX5 (0.47) | ALOX5ALDH1A1LMNATSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787127-B1 | 5-LIPOXYGENASE INHIBITORS | PFIZER (US) | 2001-01-03 | — | — | EP | disclosed |
| US-6063928-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, CARDIOTONIC AGENTS | PFIZER INC (US) | 2000-05-16 | — | — | US | disclosed |
| US-5883106-A | 5-lipoxygenase inhibitors | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |