Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13365169 | 0.89 | OPRD1 (0.47) | ALDH1A1OPRD1DRD3OPRM1OPRK1 | |
| SCHEMBL12020311 | 0.85 | HDAC4 (0.49) | OPRD1DRD3OPRM1 | |
| SCHEMBL7811090 | 0.84 | ALOX5 (0.51) | ALOX5ALDH1A1LMNADRD3TSHR | |
| SCHEMBL27078112 | 0.84 | CYP2C19 (0.45) | ALOX5ALDH1A1CYP2C19NPC1MAPT | |
| SCHEMBL29731283 | 0.84 | CYP2C19 (0.45) | ALOX5ALDH1A1CYP2C19NPC1MAPT | |
| SCHEMBL12638722 | 0.83 | ALOX5 (0.44) | ALOX5ALDH1A1CYP2C19NPC1MAPT | |
| SCHEMBL24780844 | 0.82 | ALDH1A1 (0.62) | ALDH1A1CYP2C19NPC1MAPTCYP2C9 | |
| SCHEMBL9136332 | 0.80 | ALOX5 (0.54) | ALOX5ALDH1A1CYP2C19OPRD1LMNA | |
| SCHEMBL15733769 | 0.80 | OPRD1 (0.63) | OPRD1DRD3OPRM1OPRK1 | |
| SCHEMBL7809110 | 0.77 | ALOX5 (0.47) | ALOX5ALDH1A1CYP2C19NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462830-B1 | Cyclic ether derivatives | ZENECA LTD (GB) | 1995-10-18 | — | — | EP | disclosed |
| US-5407945-A | Pyran derivatives and their use as inhibitors of 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES, INC. (GB) | 1995-04-18 | — | — | US | disclosed |
| US-5254581-A | Used in the treatment of various inflammatory and allergic diseases | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0462830-A2 | Cyclic ether derivatives | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |