SCHEMBL7811288

SCHEMBL7811288

COc1ccc(NC(=O)Cn2c(=O)c3cc(OC)ccc3n2S(=O)(=O)c2ccc(C)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 3/20 0.49
MAPT P10636 2/20 0.49
ALDH1A1 P00352 4/20 0.48
CHRNB2 P17787 2/20 0.48
CHRNB4 P30926 2/20 0.48
CHRNA3 P32297 2/20 0.48
CHRNA4 P43681 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
POLB P06746 1/20 0.48
HTR6 P50406 2/20 0.48
KMT2A Q03164 1/20 0.48
GAA P10253 3/20 0.48
CYP1A2 P05177 2/20 0.48
CYP3A4 P08684 2/20 0.48
CYP2C19 P33261 2/20 0.48
CYP2D6 P10635 1/20 0.48
USP2 O75604 1/20 0.47
TP53 P04637 1/20 0.47
TSHR P16473 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7825345 0.91 KCNA5 (0.48) KCNA5MAPTSMN1; SMN2POLBTP53
SCHEMBL7815264 0.83 MARK4 (0.51) MAPTPOLBHTR6KMT2ATP53
SCHEMBL8139948 0.81 MAPT (0.45) KCNA5MAPTSMN1; SMN2POLBKMT2A
SCHEMBL7818699 0.77 TP53 (0.52) MAPTSMN1; SMN2HTR6CYP3A4CYP2D6
SCHEMBL7854322 0.76 LMNA (0.44) MAPTALDH1A1SMN1; SMN2HTR6CYP1A2
SCHEMBL7814384 0.76 HTR6 (0.45) MAPTPOLBHTR6TP53
SCHEMBL7969050 0.76 HTR6 (0.47) MAPTALDH1A1POLBHTR6KMT2A
SCHEMBL7978978 0.75 TP53 (0.52) MAPTHTR6CYP1A2CYP3A4CYP2C19
SCHEMBL7825347 0.75 SMN1; SMN2 (0.45) KCNA5ALDH1A1SMN1; SMN2POLBTP53
SCHEMBL7980485 0.75 NOX4 (0.44) POLBHTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1077948-A1 NOVEL 1,2,5-TRISUBSTITUTED 1,2-DIHYDRO-INDAZOL-3-ONES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS A MEDICAMENT ARZNEIMITTELWERK DRESDEN GMBH (DE) 2001-02-28 EP claimed
US-6180637-B1 THERAPY FOR PARKINSON, ALZHEIMER DISEASE ARZNEIMITTELWERK DRESDEN GMBH (DE) 2001-01-30 US claimed
WO-1999058504-A9 NOVEL 1,2,5-TRISUBSTITUTED 1,2-DIHYDRO-INDAZOL-3-ONES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS A MEDICAMENT DRESDEN ARZNEIMITTEL (DE) 2000-02-03 WO claimed
WO-1999058504-A1 NOVEL 1,2,5-TRISUBSTITUTED 1,2-DIHYDRO-INDAZOL-3-ONES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS A MEDICAMENT ARZNEIMITTELWERK DRESDEN GMBH (DE) 1999-11-18 WO claimed
US-6180637-B1 THERAPY FOR PARKINSON, ALZHEIMER DISEASE ARZNEIMITTELWERK DRESDEN GMBH (DE) 2001-01-30 US disclosed