Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 7/20 | 0.46 |
| ▸ | TDO2 | P48775 | 5/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811377 | 0.72 | IDO1 (0.52) | IDO1TDO2GLAPKMMAOB | |
| SCHEMBL7811740 | 0.70 | IDO1 (0.45) | IDO1TDO2GLAALOX5ALDH1A1 | |
| SCHEMBL7811891 | 0.69 | IDO1 (0.55) | IDO1TDO2PKMALDH1A1POLB | |
| SCHEMBL7805846 | 0.68 | IDO1 (0.48) | IDO1TDO2ALDH1A1NPC1POLB | |
| SCHEMBL7808047 | 0.66 | IDO1 (0.79) | IDO1TDO2ALDH1A1POLB | |
| SCHEMBL7811786 | 0.65 | IDO1 (0.53) | IDO1TDO2ALDH1A1NPC1MAPT | |
| SCHEMBL7816362 | 0.65 | IDO1 (0.55) | IDO1TDO2ALDH1A1NPC1MAPT | |
| SCHEMBL7805902 | 0.65 | IDO1 (0.63) | IDO1TDO2ALDH1A1NPC1MAPT | |
| SCHEMBL7812948 | 0.65 | IDO1 (0.52) | IDO1TDO2ALDH1A1NPC1MAPT | |
| SCHEMBL7807731 | 0.65 | IDO1 (0.52) | IDO1TDO2MAOBALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | claimed |